Naslov
Clinical and neurophysiological changes in patients with pineal region expansions

Autori
Hajnšek, Sanja ; Paladino, Josip ; Petelin, Željka ; Nanković, Sibila ; Mrak, Goran ; Lupret, Velimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta clinica Croatica, suppl. 1 / Rotim, Krešimir ; Ledić, Darko - Zagreb : Klinički bolnički centar Zagreb (KBC Zagreb), 2011, 45-45

Skup
6th Congress Of The Croatian Neurosurgical Society and the Joint Meeting with The Slovenian Neurosurgical Society

Mjesto i datum
Opatija, Hrvatska, 25.05.2011. - 28.05.2011

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pineal expansions; neurophysiology; clinical changes

Sažetak
Aim of the study: In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities. We decided to perform retrospective study which included 84 patients in the period from 1992 to 2010. Methods: The study included 55 women and 29 men, mean age 30.08± 13.93 years, with positive brain MRI - 70 patients (83.4%) had simple pineal gland cysts, and 14 patients (16.67%) had expansive process in pineal region with compressive effect. Operation with supracerebellar infratentorial approach was performed in 70 patients. Pathohistological analysis revealed pineocytomas in 11 cases, pinealoblastomas in 2 cases, one case of teratoma, while other patients had pineal gland cysts. Results: All patients had “dysrrhytmic headache“, while 32 patients (38%) had epileptic phenomena - primary generalized seizures. Patients had common EEG pattern with paroxysmal discharges of 3 Hz (or more than 3 Hz) spike-and-wave complexes. Conclusions: This study points to often appearance of seizures that clinically and neurophysiologically present as primary generalized epilepsy in patients with pineal region expansions. Our hypotheses are that mass effect on the surrounding veins that affects normal perfusion, hemosiderin deposists, compressive effect on the quadrigeminal plate and the aqueduct of the midbrain, as well as secretion disturbances of anticonvulsive agent melatonin can be involved in the pathogenesis of seizures. We suggest to perform high resolution brain MRI with special demonstration of pineal region in all young patients that have seizures and specific EEG changes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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