Naslov
Regulatory T cells (Tregs) interplays with NKT cells in the developing of environmental diseases

Autori
Mrakovčić-Šutić, I ; Bulog, A ; Mićović, V

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The secret life of biomolecules. 10th Congress of the Croatian Society of Biochemistry and Molecular Biology with International Participation / Zrinka Kovarik and Jadranka Varljen - Opatija : Fintrade & Tours, 2010

Skup
The secret life of biomolecules. 10th Congress of the Croatian Society of Biochemistry and Molecular Biology with International Participation

Mjesto i datum
Opatija, Hrvatska, 20.09.2010. - 25.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
environmental diseases; NKT cells; regulatory T cells

Sažetak
Introduction: The occurrence of environmental diseases, especially in high industrial countries, has been increasing more than 30% for the last few decades and these illnesses are an onerous burden both to the individual and to the public health. They include all disturbances caused by environmental and behavioral factors. Environmental factors represent the group of changeable outdoor and indoor environments, while behavioral influences involve the augmentation in immunizations as a result of frequent infections, non regular use of antibiotics, diminished physical activities and decreased outdoor staying. Augmentation of NKT cells is associated with antitumor and allergic immune response, chronic inflammatory conditions, viral infection and autoimmune diseases. These cells share properties of natural killer and conventional T cells and are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognizing glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule. During their development a crucial role has an adaptor molecule SAP, encoded by the SH2D1A gene locus, which is expressed on T lymphocytes and NK cells, where it regulates cytokine production and cytotoxicity. Moderation of immune response by Tregs is characterized with specific T-cell proliferation, following with decreased secretion of T-helper 1 and T-helper 2-type cytokines Methods: Hypothesis about regulatory network of Tregs and NKT cells was studied by flow cytometry, analyzing the characteristics of human Tregs and NKT cells of inhabitants from industrial area, compared to healthy volunteers. The function of NK cells was examined by cytotoxicity assay against human NK-sensitive cell line K562. Results: inhabitants from industrial area have significantly increased the percentage of NKT and Tregs, which may interplay with the function of immune system and percentage of allergic diseases. All exposed individuals have significantly diminished values of NK-mediated cytotoxicity against human NK-sensitive target. Conclusion: NKT cells perform an important subpopolation of cells which can play both roles: as effectors and as regulatory cells in a wide range of disease settings. We can talk about the new kind of cells NKT-reg cells, whose monitoring may lead to important early diagnosis and/or prognosis of environmental diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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