Naslov
Insulin resistant brain state and drug development

Autori
Šalković-Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
10th Congress of European Society for clinical neuropharmacology

Mjesto i datum
Zagreb, Hrvatska, 21.10.2010. - 23.10.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
sporadic Alzheimer disease; streptozotocin; M30; HLA-20

Sažetak
Basic research of Alzheimer's disease (AD) is currently focused to the various transgenic mice AD models which have been designed by manipulation of genes involved generaly in the production of amyloid β peptide and tau protein, and are, therefore representing models of the familal AD form. However, more than 95% cases of AD are manifested as the sporadic form with unknown etiopathogenesis due to transgenic mice models are not good models for investigating the sAD patophysiology and for testing the novel therapeutic approaches in this disease. Rats treated intracerebroventricularly with a streptozotocin (STZ-icv rat model) have been recently proposed as a model of sAD, which similar to sAD patients, develop insulin resistant brain state. Pharmacological profile of novel, multifanctional compunds M30 and HLA20 which have iron-chelating and antioxidative capacity has been tested in STZ-icv rat model and their neuropreventive and neurorescue potential on cognitive deficits has been demonstrated. Supported by MZOŠ 108-1080003-0020 and DAAD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA