Naslov
Expression of Cytokeratin 17 in odontogenic cysts

Autori
Pavelić, Božidar ; Levanat, Sonja ; Crnić, Ivana ; Anić, Ivica ; Prskalo, Katica ; Manojlović, S

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The book of obstracts of the 9th bienial congress of the European Society of Endodontology / Anić, Ivica - Zagreb : Hrvatsko endodontsko društvo, 1999

Skup
The 9th bienial congress of the European Society of Endodontology

Mjesto i datum
Zagreb, Hrvatska, 05.10.1999. - 07.10.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytokeratin; odontogenic cyst

Sažetak
Cytokeratins constitute the main structural proteins in epithelial cells. Differences in the type and distribution of cytokeratins have been observed in a variety of oral lesions including potentially malignant lesions. The purpose of this study was to identify expression of Cytokeratin 17 (Dako, Denmark) in epithelium of odontogenic cysts. Cytokeratin 17 antibody reacts with the human 46 kDa cytokeratin protein. The antibody mainly reacts with basal cells in complex epithelia. Sporadic odontogenic keratocysts (n = 5), follicular cysts (n = 10) and radicular cysts (n = 10) were tested in an immunohistochemical study. Paraffin-embedded slices were cut at 5m. With Cytokeratin 17 a positive reaction was detected in the epithelium of sporadic keratocysts, but epithelium of follicular and radicular cysts showed a negative reaction. The results suggested that Cytokeratin 17 could be a good marker for distinguishing sporadic keratocysts from radicular and follicular cysts in clinical cases where histological diagnosis is not straightforward. For routine use of these markers in clinical diagnosis, more extensive study should be done, with a larger number of samples and exclusion of all possible nonspecific components in specimens that could possibly give a positive reaction.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA