Naslov
Translational optimization and functional adaptation across microbial communities

Autori
Roller, Maša ; Lucić, Vedran ; Perica, Tina ; Vlahoviček, Kristian

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EMBO YIP PhD Course, Spotlights on Current Biology / Gerlind Wallon - , 2010, 13-13

Skup
EMBO YIP PhD Course 2010

Mjesto i datum
Heidelberg, Njemačka, 20.09.2010. - 25.09.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
metagenomics; codon usage; translational optimization

Sažetak
Metagenomics projects sequence microbial communities’ genomes to shed light on the myriad of genetic capabilities that enable them to inhabit virtually every corner of the biosphere. Computational analyses of genetic content in numerous completed metagenomic projects to date have been limited to counting genes and their respective functions found in an environment, and to phylogenetic classification of sequenced samples. We explore well-established concepts of translational optimization and codon adaptation studies, proven relevant at the level of single bacterial genomes, on metagenomic datasets from 8 distinct environments. We show that all microbial species in a metagenome, regardless of their phylogenetic distribution, also share similar codon usage bias in genes optimized at the translational level, specifically ribosomal protein genes and genes required for adaptation to specific environments. In this respect, we have found evidence that microbial communities indeed behave as meta- genomes, which enables us to track functional adaptations of entire communities to diverse environments.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA