Naslov
Ganglia/Nerve Fibers Ratio Correlates with the Need for Surgery in Patients Diagnosed with Hirschsprung's Disease Allied Disorder (HAD)

Autori
Gašparović, Ivan ; Kovač, Dražen ; Peršić, Mladen ; Slavić, Irena ; Nikolić, Hari ; Jonjić, Nives

Izvornik
Fetal and pediatric pathology (1551-3815) 30 (2011), 6; 405-413

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hirschsprung's disease Allied Disorder (HAD); Ganglia/Nerve Fibers Ratio

Sažetak
Treatment in Hirschsprung's disease allied disorder (HAD) is surgical. In HAD, surgery is always a question. We investigated the value of ganglia/nerve fibers ratio in prediction of the need for invasive procedures in HAD. Sections of full thickness bowel specimens of 14 patients were stained with antibodies marking ganglia (Anti-Neuron-Specific Enolase, Anti-NSE) and marking nerve fibers (S-100). Six out of seven patients indicated for surgery had low ganglia/nerve fibers ratio. Five out of seven patients, not showing the need for surgery, had high ganglia/nerve fibers ratio. We propose that a lower ganglia/nerve fiber ratio can be used as a predictor of increased need for surgery in HAD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA