Naslov
Stable gastric pentadecapeptide BPC 157 may heal duodenocutaneous fistulas in rats

Autori
Škorjanec, Sandra ; Dolovski, Zdravko ; Sever, Marko ; Kliček, Robert ; Drmić, Domagoj ; Radić, Božo ; Brčić, Luka ; Kolenc, Danijela ; Boban Blagaić, Alenka ; Jelaska, Aida ; Gjurašin, Miroslav ; Turković, Branko ; Seiwerth, Sven ; Ručman, Rudolf ; Sikirić, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1) / - , 2011, S-656

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
stable gastric pentadecapeptide BPC 157; duodenocutaneous fistulas; rats

Sažetak
We investigate the healing of duodenocutaneous fistulas in rats and stable gastric pentadecapeptide BPC 157. We recently focused on unhealed gastrocutaneous fistulas (2-mm-diameter stomach defect, 3-mm-diameter skin defect) to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Therefore, with the fistulas therapy, we challenge the wound/growth factors theory of the analogous nonhealing of wounds and persistent gastric ulcers. We suggested that the healing rate of gastrocutaneous fistula in rats validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 lg/kg) (12 ml/rat/day) or intraperitoneally (10 lg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery ; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]. We clearly demonstrated a greater anti-ulcer potential and efficiency in wound healing compared with standard agents, favoring BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally. Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. Standard anti-ulcer agents, after a delay, improve firstly skin healing and then stomach mucosal healing, but not fistula leaking and bursting strength (except for atropine). Now, we demonstrated that unhealed duodenocutaneous fistula while with more severe course, may have the most rapid healing with pentadecapeptide BPC 157 regimens, given intrapetitoneally or in drinking water. Conclusion. BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers as well as duodenal ulcers better than standard agents, and thereby, BPC 157 may be successfully applied in further therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA