Pregled bibliografske jedinice broj: 551369
Lack of Association between TNF-α Promoter Polymorphism and Prostate Carcinoma Susceptibility in Eastern Croatian Population
Lack of Association between TNF-α Promoter Polymorphism and Prostate Carcinoma Susceptibility in Eastern Croatian Population // Collegium antropologicum, 37 (2013), 4; 1199-1202 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 551369 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Lack of Association between TNF-α Promoter Polymorphism and Prostate Carcinoma Susceptibility in Eastern Croatian Population
Autori
Horvat, Vesna ; Sudarević, Bojan ; Ćosić, Ivan ; Miličević, Nevenka ; Bošnjak, Silvana ; Mandić, Sanja ; Marczi, Saška ; Šimunović, Dalibor ; Galić, Josip
Izvornik
Collegium antropologicum (0350-6134) 37
(2013), 4;
1199-1202
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
prostate cancer; tumor necrosis factor-alpha; polymorphism
Sažetak
A single nuclear polymorphisms (SNPs) in the promoter region of the tumor necrosis factor-alpha (TNF-α) gene are involved in regulation of expression levels of TNF-α and therefore are associated with oncogenesis of several cancers. Aim of our study was to investigate the effect of G→A polymorphism at –308 position in the promoter region of the TNF-α gene on prostate cancer (CaP) susceptibility in a subset of patients from Eastern Croatia. Study population consisted of 240 patients (120 with CaP, 120 controls). They were genotyped for TNF-α G-308A polymorphism using real-time PCR (LightCycler Instrument, Roche Diagnostics) and melting curve analysis method. 2 test was used to compare distribution of TNF-α polymorphism genotypes between patients and control group. Relative risk was estimated by the odds ratio (OR). There was no significant statistical difference (2=0.000, DF=1, p=1, OR=1, 95%CI=0.5537-1.8059) between patients and control group. Besides, data of CaP patients were stratified by pathohistological diagnosis (PHD) and Gleason score and groups were compared according to TNF- genotypes. Also, all patients and CaP patients were grouped according to prostate volume (V) into three groups: V<50ml, V50-100ml, V>100ml. These groups were also compared according to TNF- genotypes. There were no significant statistical differences between any of groups. Our findings suggest that TNF-α –308 SNP is not associated with CaP in Eastern Croatia population.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
219-0000000-3363 - Imunološki čimbenici razvoja i progresije karcinoma prostate (Galić, Josip, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE