Naslov
Botulinum toxin's axonal transport from periphery to the spinal cord

Autori
Matak, Ivica ; Riederer, Peter ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
The 8th International Medical Postgraduate Conference- new frontiers in the research of PhD students / Horaček, Jiri - Hradec Kralove : Astraprint, Hradec Kralove, 2011, 68-71

ISBN
978-80-260-0922-1

Skup
The 8th International Medical Postgraduate Conference- new frontiers in the research of PhD students- Conference of Medical Schools

Mjesto i datum
Hradec Králové, Češka Republika, 10.11.2011. - 12.11.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
botulinum toxin; axonal transport; spinal cord

Sažetak
Botulinum toxin type A (BTX-A) is widely used as a treatment for various types of muscular hyperactivity disorders like focal dystonias and spasticity, presumably due to its neuromuscular blocking properties exerted by peripheral synaptosomal-associated protein 25 (SNAP-25) cleavage. However, recently, retrograde axonal transport of BTX-A has been demonstrated by immunohistochemistry (Antonucci et al., 2009, Matak et al., 2011) and behavioral experiments (Bach-Rojecky & Lacković, 2009). In this study we employed BTX-A-cleaved SNAP-25 immunohistochemistry of spinal cord motor neurons after peripheral intramuscular, subcutaneous or intraneural BTX-A (hind-limb or sciatic nerve) injections. We demonstrate the cleavage of central SNAP-25 in ipsilateral spinal cord ventral horns and dorsal horns after single peripheral BTX-A administration, even at low peripheral dose applied (5 U/kg). These results extend the recent findings on BTX-A retrograde axonal transport in facial and trigeminal nerve. Study with low-dose BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application.

Izvorni jezik
Engleski

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