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Pregled bibliografske jedinice broj: 551210

Nix is a selective autophagy receptor for mitochondrial clearance

Novak, Ivana; Kirkin, Vladimir; McEwan, David G.; Zhang, Ji; Wild, Philipp; Rozenknop, Alexis; Rogov, Vladimir; Lohr, Frank; Popovic, Doris; Occhipinti, Angelo et al.
Nix is a selective autophagy receptor for mitochondrial clearance // EMBO reports, 11 (2010), 1; 45-51 doi:10.1038/embor.2009.256 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 551210 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Nix is a selective autophagy receptor for mitochondrial clearance

Autori
Novak, Ivana ; Kirkin, Vladimir ; McEwan, David G. ; Zhang, Ji ; Wild, Philipp ; Rozenknop, Alexis ; Rogov, Vladimir ; Lohr, Frank ; Popovic, Doris ; Occhipinti, Angelo ; Reichert, Andreas S. ; Terzić, Janoš ; Doetsch, Volker ; Ney, Paul A. ; Đikić, Ivan

Izvornik
EMBO reports (1469-221X) 11 (2010), 1; 45-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
reticulocyte maturation; cell-death; structural basis; mitophagy; degradation; ubiquitin; BNIP3; apoptosis; protein; E3

Sažetak
Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy mediates selective removal of protein aggregates, organelles and microbes in cells. Yet, the specificity in targeting a particular substrate to the autophagy pathway remains poorly understood. Here, we show that the mitochondrial protein Nix is a selective autophagy receptor by binding to LC3/GABARAP proteins, ubiquitin-like modifiers that are required for the growth of autophagosomal membranes. In cultured cells, Nix recruits GABARAP-L1 to damaged mitochondria through its amino-terminal LC3-interacting region. Furthermore, ablation of the Nix: LC3/GABARAP interaction retards mitochondrial clearance in maturing murine reticulocytes. Thus, Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
216-0000000-3348 - ULOGA UPALNIH PROCESA U NASTANKU MALIGNIH TUMORA (Terzić, Janoš, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split,
Mediteranski institut za istraživanje života

Profili:

Avatar Url Ivana Novak Nakir (autor)

Avatar Url Tong Zhang (autor)

Avatar Url Janoš Terzić (autor)

Avatar Url Ivan Đikić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Novak, Ivana; Kirkin, Vladimir; McEwan, David G.; Zhang, Ji; Wild, Philipp; Rozenknop, Alexis; Rogov, Vladimir; Lohr, Frank; Popovic, Doris; Occhipinti, Angelo et al.
Nix is a selective autophagy receptor for mitochondrial clearance // EMBO reports, 11 (2010), 1; 45-51 doi:10.1038/embor.2009.256 (međunarodna recenzija, članak, znanstveni)
Novak, I., Kirkin, V., McEwan, D., Zhang, J., Wild, P., Rozenknop, A., Rogov, V., Lohr, F., Popovic, D. & Occhipinti, A. (2010) Nix is a selective autophagy receptor for mitochondrial clearance. EMBO reports, 11 (1), 45-51 doi:10.1038/embor.2009.256.
@article{article, author = {Novak, Ivana and Kirkin, Vladimir and McEwan, David G. and Zhang, Ji and Wild, Philipp and Rozenknop, Alexis and Rogov, Vladimir and Lohr, Frank and Popovic, Doris and Occhipinti, Angelo and Reichert, Andreas S. and Terzi\'{c}, Jano\v{s} and Doetsch, Volker and Ney, Paul A. and \DJiki\'{c}, Ivan}, year = {2010}, pages = {45-51}, DOI = {10.1038/embor.2009.256}, keywords = {reticulocyte maturation, cell-death, structural basis, mitophagy, degradation, ubiquitin, BNIP3, apoptosis, protein, E3}, journal = {EMBO reports}, doi = {10.1038/embor.2009.256}, volume = {11}, number = {1}, issn = {1469-221X}, title = {Nix is a selective autophagy receptor for mitochondrial clearance}, keyword = {reticulocyte maturation, cell-death, structural basis, mitophagy, degradation, ubiquitin, BNIP3, apoptosis, protein, E3} }
@article{article, author = {Novak, Ivana and Kirkin, Vladimir and McEwan, David G. and Zhang, Ji and Wild, Philipp and Rozenknop, Alexis and Rogov, Vladimir and Lohr, Frank and Popovic, Doris and Occhipinti, Angelo and Reichert, Andreas S. and Terzi\'{c}, Jano\v{s} and Doetsch, Volker and Ney, Paul A. and \DJiki\'{c}, Ivan}, year = {2010}, pages = {45-51}, DOI = {10.1038/embor.2009.256}, keywords = {reticulocyte maturation, cell-death, structural basis, mitophagy, degradation, ubiquitin, BNIP3, apoptosis, protein, E3}, journal = {EMBO reports}, doi = {10.1038/embor.2009.256}, volume = {11}, number = {1}, issn = {1469-221X}, title = {Nix is a selective autophagy receptor for mitochondrial clearance}, keyword = {reticulocyte maturation, cell-death, structural basis, mitophagy, degradation, ubiquitin, BNIP3, apoptosis, protein, E3} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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