Naslov
Natural killer T cells in pulmonary disorders

Autori
Rijavec, Matija ; Volarević, Siniša ; Osolnik, Katarina ; Kosnik, Mitja ; Korošec, Peter

Izvornik
Respiratory medicine (0954-6111) 105 (2011), S1; S0-S25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
asthma; COPD; hypersensitivity; lung cancer; NKT cells; pneumonitis; sarcoidosis; tuberculosis

Sažetak
Natural killer T (NKT) cells, a unique subgroup of lymphocytes with features of both T and natural killer (NK) cells, represent a bridge between innate and adaptive immunity. They have the ability to either promote or suppress immune responses. With these immunoregulatory functions, NKT cells have emerged as an important subset of lymphocytes with a protective role in some disorders, such as infections, cancer, and possibly sarcoidosis, and a pathogenic role in others, such as asthma, chronic obstructive pulmonary disease and hypersensitivity pneumonitis. Immunotherapeutic interventions to modulate the immune response by targeting iNKT cell functions has become a challenging field and has shown promising results for the development of new therapies

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA