Pregled bibliografske jedinice broj: 549830
Interactions of acyclic and cyclic polyamines with DNA and RNA
Interactions of acyclic and cyclic polyamines with DNA and RNA // The 3rd EuCheMS Chemistry
Nürnberg, Njemačka, 2010. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 549830 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Interactions of acyclic and cyclic polyamines with DNA and RNA
Autori
Piantanida, Ivo ; García-España, E. ; Sornosa-Ten, A. ; Albelda, M.T. ; Frías, J.C ; Llinares, J.M. ; Budimir, Ana ; González Garcia, J.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
The 3rd EuCheMS Chemistry
Mjesto i datum
Nürnberg, Njemačka, 28.08.2010. - 03.09.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
cyclic polyamines; DNA; RNA; selectivity
Sažetak
A series of novel cyclic polyamines differing from acyclic derivatives in a number of positive charges, as well as in type and location of heteroaromatic moieties were studied for binding ability to double stranded DNA and RNA. All applied methods (UV/vis, fluorimetric, CD titrations, melting experiments) consistently support binding of cyclic polyamines within the DNA minor groove, while for ds-RNA binding mode is not clearly defined. Both, acyclic (A) and cyclic (B) polyamines reveal pronounced ds-RNA over ds-DNA selectivity, whereby selectivity of cyclic derivatives depends on a core moiety (pyridine vs. phenanthroline).
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb
