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Pregled bibliografske jedinice broj: 549584

Variation in GNB3 predicts response and adverse reactions to antidepressants

Keers, R.; Bonvicini, C.; Scassellati, C.; Uher, R.; Placentino, A.; Giovannini, C.; Rietschel, M.; Henigsberg, Neven; Kozel, D.; Mors, O. et al.
Variation in GNB3 predicts response and adverse reactions to antidepressants // Journal of psychopharmacology, 25 (2011), 7; 867-874 doi:10.1177/0269881110376683 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 549584 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Variation in GNB3 predicts response and adverse reactions to antidepressants

Autori
Keers, R. ; Bonvicini, C. ; Scassellati, C. ; Uher, R. ; Placentino, A. ; Giovannini, C. ; Rietschel, M. ; Henigsberg, Neven ; Kozel, D. ; Mors, O. ; Maier, W. ; Hauser, J. ; Souery, D. ; Mendlewicz, J. ; Schmäl, C. ; Zobel, A. ; Larsen, E.R. ; Szczepankiewicz, A. ; Kovačić, Zrnka ; Elkin, A. ; Craig, I. ; McGuffin, P. ; Farmer, A.E. ; Aitchison, K.J. ; Gennarelli. M.

Izvornik
Journal of psychopharmacology (0269-8811) 25 (2011), 7; 867-874

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
major depressive disorder; antidepressive agent; pharmacogenetics; GNB3; G protein

Sažetak
There is substantial inter-individual variation in response and adverse reactions to antidepressants, and genetic variation may, in part, explain these differences. GNB3 encodes the β3 subunit of the G protein complex, which is involved in the downstream signalling cascade following monoamine receptor activation. A functional polymorphism in this gene (C825T) has been associated with response to antidepressants. Several lines of evidence suggest that GNB3 moderates improvement in the neurovegetative symptoms of depression (such as sleep and appetite) and related adverse reactions independently of change in core mood symptoms. We here report analysis of data from GENDEP, a part-randomized pharmacogenomic trial, on the outcome of 811 subjects with major depression undergoing treatment with either escitalopram or nortriptyline in which the C825T SNP and three further SNPs in GNB3 were genotyped. The TT genotype was significantly associated with a superior response to nortriptyline and these effects were specific to improvements in neurovegetative symptoms. In addition, the same genotype predicted fewer incidents of treatment-emergent insomnia and greater weight gain on the same drug. Our results are consistent with previous associations with GNB3 and emphasize the importance of signalling genes in antidepressant response.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1880 - 1H-MRS promjene u predviđanju terapijskog odgovora, relapsa i povrata depresije (Henigsberg, Neven, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Avatar Url Zrnka Kovačić Petrović (autor)

Poveznice na cjeloviti tekst rada:

doi jop.sagepub.com

Citiraj ovu publikaciju:

Keers, R.; Bonvicini, C.; Scassellati, C.; Uher, R.; Placentino, A.; Giovannini, C.; Rietschel, M.; Henigsberg, Neven; Kozel, D.; Mors, O. et al.
Variation in GNB3 predicts response and adverse reactions to antidepressants // Journal of psychopharmacology, 25 (2011), 7; 867-874 doi:10.1177/0269881110376683 (međunarodna recenzija, članak, znanstveni)
Keers, R., Bonvicini, C., Scassellati, C., Uher, R., Placentino, A., Giovannini, C., Rietschel, M., Henigsberg, N., Kozel, D. & Mors, O. (2011) Variation in GNB3 predicts response and adverse reactions to antidepressants. Journal of psychopharmacology, 25 (7), 867-874 doi:10.1177/0269881110376683.
@article{article, author = {Keers, R. and Bonvicini, C. and Scassellati, C. and Uher, R. and Placentino, A. and Giovannini, C. and Rietschel, M. and Henigsberg, Neven and Kozel, D. and Mors, O. and Maier, W. and Hauser, J. and Souery, D. and Mendlewicz, J. and Schm\"{a}l, C. and Zobel, A. and Larsen, E.R. and Szczepankiewicz, A. and Kova\v{c}i\'{c}, Zrnka and Elkin, A. and Craig, I. and McGuffin, P. and Farmer, A.E. and Aitchison, K.J.}, year = {2011}, pages = {867-874}, DOI = {10.1177/0269881110376683}, keywords = {major depressive disorder, antidepressive agent, pharmacogenetics, GNB3, G protein}, journal = {Journal of psychopharmacology}, doi = {10.1177/0269881110376683}, volume = {25}, number = {7}, issn = {0269-8811}, title = {Variation in GNB3 predicts response and adverse reactions to antidepressants}, keyword = {major depressive disorder, antidepressive agent, pharmacogenetics, GNB3, G protein} }
@article{article, author = {Keers, R. and Bonvicini, C. and Scassellati, C. and Uher, R. and Placentino, A. and Giovannini, C. and Rietschel, M. and Henigsberg, Neven and Kozel, D. and Mors, O. and Maier, W. and Hauser, J. and Souery, D. and Mendlewicz, J. and Schm\"{a}l, C. and Zobel, A. and Larsen, E.R. and Szczepankiewicz, A. and Kova\v{c}i\'{c}, Zrnka and Elkin, A. and Craig, I. and McGuffin, P. and Farmer, A.E. and Aitchison, K.J.}, year = {2011}, pages = {867-874}, DOI = {10.1177/0269881110376683}, keywords = {major depressive disorder, antidepressive agent, pharmacogenetics, GNB3, G protein}, journal = {Journal of psychopharmacology}, doi = {10.1177/0269881110376683}, volume = {25}, number = {7}, issn = {0269-8811}, title = {Variation in GNB3 predicts response and adverse reactions to antidepressants}, keyword = {major depressive disorder, antidepressive agent, pharmacogenetics, GNB3, G protein} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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