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Pregled bibliografske jedinice broj: 549555

Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants

Malki, K.; Uher, R.; Paya-Cano, J.; Binder, E.; Rietschel, M.; Zobel, A.; Mors, O.; Hauser, J.; Henigsberg, Neven; Jerman, B. et al.
Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants // Biological psychiatry, 69 (2011), 4; 360-365 doi:10.1016/j.biopsych.2010.08.011 (međunarodna recenzija, članak, znanstveni)

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Naslov
Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants

Autori
Malki, K. ; Uher, R. ; Paya-Cano, J. ; Binder, E. ; Rietschel, M. ; Zobel, A. ; Mors, O. ; Hauser, J. ; Henigsberg, Neven ; Jerman, B. ; Souery, D. ; Placentino, A. ; Ng M.Y. ; Cohen-Woods, S. ; Sluyter, F. ; Farmer, A. ; Aitchison, K.J. ; Craig, I.W. ; Lewis, C.M. ; McGuffin, P. ; Schalkwyk, L.C.

Izvornik
Biological psychiatry (0006-3223) 69 (2011), 4; 360-365

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antidepressants; escitalopram; GENDEP; nortriptyline; pharmacogenetic; PPM1A

Sažetak
Antidepressant drugs are used as first-line treatment in depression, but response has been shown to be highly heterogeneous, with drugs often failing to have the desired therapeutic effect. We report on an integrative analysis from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study using gene expression from mice to inform prioritization in a human pharmacogenetic study. The same two antidepressants were used in mice and humans: escitalopram (a serotonin reuptake inhibitor) and nortriptyline (a norepinephrine reuptake inhibitor). The animal study used four inbred strains of mice (129S1/SvlmJ, C57LB/6J, DBA/2J, and FVB/NJ). Hippocampus mRNA levels were measured in 144 animals using the Affymetrix MOE 430 v2 chip. Based on gene-expression analysis of strain-by-drug interactions, 17 genes differentially expressed with nortriptyline or escitalopram versus saline were prioritized in the human pharmacogenetic analysis. Single nucleotide polymorphisms tagging common sequence variation in human orthologs of these genes were tested for association with response to antidepressants in 706 participants of the GENDEP human pharmacogenetic study, treated with escitalopram or nortriptyline for 12 weeks, with available high-quality Illumina 610 quad array genotyping. Several polymorphisms in the protein phosphatase 1A gene (PPM1A) remained significantly associated with response to nortriptyline in humans after correction for multiple comparisons within the gene. PPM1A encodes a phosphatase involved in mitogen-activated protein kinase signaling and cell stress response. Convergent evidence from mice and humans suggests a role of the PPM1A in response to noradrenergic but not serotonergic antidepressants.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1880 - 1H-MRS promjene u predviđanju terapijskog odgovora, relapsa i povrata depresije (Henigsberg, Neven, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.biologicalpsychiatryjournal.com

Citiraj ovu publikaciju:

Malki, K.; Uher, R.; Paya-Cano, J.; Binder, E.; Rietschel, M.; Zobel, A.; Mors, O.; Hauser, J.; Henigsberg, Neven; Jerman, B. et al.
Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants // Biological psychiatry, 69 (2011), 4; 360-365 doi:10.1016/j.biopsych.2010.08.011 (međunarodna recenzija, članak, znanstveni)
Malki, K., Uher, R., Paya-Cano, J., Binder, E., Rietschel, M., Zobel, A., Mors, O., Hauser, J., Henigsberg, N. & Jerman, B. (2011) Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants. Biological psychiatry, 69 (4), 360-365 doi:10.1016/j.biopsych.2010.08.011.
@article{article, author = {Malki, K. and Uher, R. and Paya-Cano, J. and Binder, E. and Rietschel, M. and Zobel, A. and Mors, O. and Hauser, J. and Henigsberg, Neven and Jerman, B. and Souery, D. and Placentino, A. and Cohen-Woods, S. and Sluyter, F. and Farmer, A. and Aitchison, K.J. and Craig, I.W. and Lewis, C.M. and McGuffin, P. and Schalkwyk, L.C.}, year = {2011}, pages = {360-365}, DOI = {10.1016/j.biopsych.2010.08.011}, keywords = {antidepressants, escitalopram, GENDEP, nortriptyline, pharmacogenetic, PPM1A}, journal = {Biological psychiatry}, doi = {10.1016/j.biopsych.2010.08.011}, volume = {69}, number = {4}, issn = {0006-3223}, title = {Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants}, keyword = {antidepressants, escitalopram, GENDEP, nortriptyline, pharmacogenetic, PPM1A} }
@article{article, author = {Malki, K. and Uher, R. and Paya-Cano, J. and Binder, E. and Rietschel, M. and Zobel, A. and Mors, O. and Hauser, J. and Henigsberg, Neven and Jerman, B. and Souery, D. and Placentino, A. and Cohen-Woods, S. and Sluyter, F. and Farmer, A. and Aitchison, K.J. and Craig, I.W. and Lewis, C.M. and McGuffin, P. and Schalkwyk, L.C.}, year = {2011}, pages = {360-365}, DOI = {10.1016/j.biopsych.2010.08.011}, keywords = {antidepressants, escitalopram, GENDEP, nortriptyline, pharmacogenetic, PPM1A}, journal = {Biological psychiatry}, doi = {10.1016/j.biopsych.2010.08.011}, volume = {69}, number = {4}, issn = {0006-3223}, title = {Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants}, keyword = {antidepressants, escitalopram, GENDEP, nortriptyline, pharmacogenetic, PPM1A} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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