Naslov
Testicular germ cell cancer incidence in Eastern Slavonia

Autori
Radoja, Ivan ; Sudarević, Bojan ; Šimunović, Dalibor ; Galić, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Urology, Supplements / - , 2011, 643-643

Skup
European Association of Urology 11th Central European Meeting

Mjesto i datum
Temišvar, Rumunjska, 28.10.2011. - 29.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
testis tumor ; incidence

Sažetak
Introduction By analyzing data from our department ranging from 1969 to 2010 and latest reports by the Croatian National Cancer Registry (2001-2008), we have noticed increase in the incidence of testicular germ cell carcinoma (TGCC) in the population of Eastern Croatia. Our hypothesis is based on the assumption that Chernobyl accident in 1986, Croatian War of Independence (1991-1995) and Bosnian War (1992- 1995) are causative agents that best depict this phenomenon. Recent studies have shown that testicular cancer incidence is also rising among North European countries, especially in Balkan War veterans, consisting of military personel involved in the Kosovo War (1998-1999), hence the term “Balkan War Syndrome”. Suggested culprit for the development TGCC, not only in our population but in these veterans, is associated stress and contamination of the environment with depleted uranium (DU) from ammunitions used in the above mentioned armed conflicts. Adverse effects of Chernobyl accident are also very well known. The aim of our study was to show possible connection between war- related stress, exposure to DU, change in the pattern of the frequency of TGCC and presentation of the disease in terms of histology and stage. Patients and Methods We had 188 patients operated at our department from 1969 to 2010. Mean age of patients was 32, 5 year ± SD 10, 6. For purposes of analysis, patients were assigned to one of two periods, depending on the date of diagnosis of the GCT, i.e. 1969-1995 and 1996-2010. These two periods were compared statistically to identify possible changes in the presentation of the TGCC. Seminoma was found in 41, 5% (78) of all cases, non-seminoma germinal cell tumors (NSGCT) in 53, 2% (100) cases while other types including some benign forms, lymphoma and metastasis in 5, 3% (10). Period from 1969 to 1995: 32 seminoma (19 stage I, 10 stage II, 3 stage III), 37 non- seminoma (18 stage I, 14 stage II, 5 stage III), 2 other, total 71. Period from 1996 to 2010: 46 seminoma (33 stage I, 11 stage II, 2 stage III), 63 non-seminoma (27 stage I, 15 stage II, 21 stage III), 8 other, total 117. Results There is 2, 8 times higher incidence rate for seminomas after 1995, 3, 2 times higher incidence rate for non-seminomas after 1995, and 3, 2 times higher incidence rate for all types of tumors after 1995. There is significant change in histology appearance of NSGCT in this two selected periods. Discussion This study gives support for the hypothesis that war-related stress and especially exposure to the DU in the Eastern Slavonia could lead to testicular malignancies after prolonged latency. However, for the latter mentioned, no exposure assessment was performed and future follow up is necessary for evaluation of DU long term risks.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA