Naslov
Conserved signal sequences specific for processing of innate immunity antimicrobial peptides

Autori
Petrov, Dražen ; Juretić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts AMP2010 / Juretić, Davor ; Separovic, Frances - Split : Sveučilište u Splitu ; Prirodoslovno-matematički fakultet Sveučilišta u Splitu, 2010, 47-47

ISBN
978-953-7155-15-5

Skup
AMP2010 Australia-Croatia Workshop on Antimicrobial Peptides and Summer School in Biophysics PhD Programme

Mjesto i datum
Split, Hrvatska, 09.08.2010. - 14.08.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antimicrobial peptides; signal sequences; conserved

Sažetak
Antimicrobial peptides (AMPs) are molecules involved in the defense mechanisms of a wide range of organisms. It has been shown for few families of host defense peptides that different C-terminal AMPs are derived from a single family of precursor polypeptides with unique features and remarkably well conserved sequence both within and between species. We showed that, for a large set of host defense peptide sequences taken from the antimicrobial database AMPB2, the signal peptide and acidic propeptide sequences of host defense peptides are highly conserved and specific for host defense peptides. We pointed out that processing of immature host defense peptides deserves further study since it may lead to discovery of highly conserved subset of signal recognition particles and peptidases specific for such peptides. Furthermore, we used this property of signal peptides to find new mature peptides (AMPs) by searching EST using signal peptide sequence as a query for the TBLASTP. In addition, we used cluster analysis for identification of signal peptide families.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA