Naslov
Lipid bound sialic acid, PGE and histamine in head and neck cancer

Autori
Klapan, Ivica ; Katić, Vladimir ; Čulo, Filip ; Sabolović, Domagoj ; Ćuk, Višeslav

Izvornik
European journal of cancer (0014-2964) 29A (1993), 6; 839-845

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
head and neck cancer; lipid-bound sialic acid; PGE2; histamine

Sažetak
Blood concentration of lipid-bound sialic acid (LBSA), prostaglandin E (PGE) and histamine were determined in 37 patients with carcinoma of hypopharynx and larynx (supraglottic and glottic), in 12 non-cancer patients and in 10 healthy subjects. The concentration of LBSA was significantly increased in 94.4% cancer patients preoperatively and fell to somewhat lower levels within 1 month after tumour resection. In patients with complete tumour resection and no tumour recurrences within 2 years, it steadily decreased thereafter, reaching normal levels within 6-24 months after surgery, whereas in patients with tumour recurrences or incomplete tumour resection it rose again within 6 months after tumour resection. Similarly, the concentration of PGE was significantly increased in about two thirds of cancer patients (67.6%) preoperatively, dropped significantly within 1 month after tumour resection and rose again in patients with tumour recurrences. Preoperative histamine concentration was decreased in 24.3% of cancer patients and postoperatively it rose both in patients with or without tumour recurrences.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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