Naslov
Transplatation of Amniotic Membrane in Corneal Ulcers and Persistant Epithelial Defects

Autori
Gržetić-Lenac, Renata ; Merlak, Maja ; Balog, Tihomir ; Bobić, Marijana Bilen ; Dekaris, Iva

Izvornik
Collegium antropologicum (0350-6134) 35 (2011), S2; 167-169

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Cornea; amniotic membrane; ulcus cornea

Sažetak
Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n=18) or non-healing epithelial defect (n=3) unresponsive to conventional treatment were included in the study. All patients were treated by AMT. Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51±1.79 of IL-1a, 64.27±31.53 pg/mL of TNFa and 209.07±201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p<0.005). Amniotic membranes that were used contained 775.69±613.98 pg/mL of IL-1ra, 0.036±0.033 pg/mL of sTNF and 175.01±166.63 pg/mL of VEGF-R. Supporting effect of the AMT could be explained by the fact that AM secretes its natural antinflammatory antagonists IL-1ra, sTNF and VEGF-R.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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