Naslov
Hepatoregenerative Role of Bone Morphogenetic Protein-9

Autori
Šoša, Ivan ; Cvijanović, Olga ; Ćelić, Tanja ; Cuculić, Dražen ; Crnčević Orlić, Željka ; Vukelić, Lucian ; Zoričić Cvek, Sanja ; Đudarić, Luka ; Bosnar, Alan ; Bobinac, Dragica

Izvornik
Medical science monitor (1234-1010) 17 (2011), 12; 33-35

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
liver organization; bone morphogenetic protein-9; insulin

Sažetak
Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) super-family of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in hepatocytes ; therefore it is proposed to be a candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due to the portocaval shunt, insulin bypasses the organ and the liver undergoes atrophy. Parenteral administration of insulin reverses atrophy by stimulating mitogenic activity of the hepatocytes. Because BMP-9 has a signaling pathway similar to other BMPs and insulin, it is to be expected that BMP-9 has a certain regenerative role in the liver. Also supporting the above-mentioned is evidence of BMP- 9 expression in Dissè's spaces and BMP-7’s mitogenic activity in mucosal cells. However, further studies are needed to confirm the possible regenerative role of BMP-9.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA