Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study

Pašalić, Daria; Pauković, Paulina; Cvijetić, Selma; Pizent, Alica; Jurasović, Jasna; Milković-Kraus, Sanja; Dodig, Slavica; Muck- Šeler, Dorotea; Mustapić, Maja; Pivac, Nela; Feher-Turković, Lana; Pavlović, Mladen

doi:10.1089/gtmb.2011.0279

Pregled bibliografske jedinice broj: 547574

Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study

Pašalić, Daria; Pauković, Paulina; Cvijetić, Selma; Pizent, Alica; Jurasović, Jasna; Milković-Kraus, Sanja; Dodig, Slavica; Muck- Šeler, Dorotea; Mustapić, Maja; Pivac, Nela et al.

Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study // Genetic Testing and Molecular Biomarkers, 16 (2012), 6; 598-604 doi:10.1089/gtmb.2011.0279 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 547574 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prostate cancer in elderly Croatian men: 5-HT genetic polymorphisms and the influence of androgen deprivation therapy on osteopenia-a pilot study

Autori
Pašalić, Daria ; Pauković, Paulina ; Cvijetić, Selma ; Pizent, Alica ; Jurasović, Jasna ; Milković-Kraus, Sanja ; Dodig, Slavica ; Muck- Šeler, Dorotea ; Mustapić, Maja ; Pivac, Nela ; Feher-Turković, Lana ; Pavlović, Mladen

Izvornik
Genetic Testing and Molecular Biomarkers (1945-0265) 16 (2012), 6; 598-604

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostate cancer ; antiandrogen therapy ; osteopenia ; genetic polymorphisms ; serotonine receptors ; aged general population

Sažetak
The aim of this study was to determine the relationship between BMI, biochemical parameters, and 5-HT genetic polymorphisms and prostate dysfunction in elderly general population. 117 elderly men subjects (60 men without symptoms of prostate hyperplasia, 42 men with untreated benign prostatic hyperplasia (BPH), and 15 men with prostate cancer (PCa) treated with finasteride or flutamide were included. Multiple comparisons showed significant difference in age, T-score, concentration of phosphorus, calcium, CRP, and PSA between the groups. T-score was the lowest and phosphorus concentration was the highest in the PCa group. Highest PSA, proteins, calcium, and Hekal’s formula score were found in the BPH group. Patients with PCa were more frequent GG+GA carriers of 5-HT1B 1997A/G gene polymorphism (p=0.035). Univariate regression analysis showed association of PCa-treated subjets with age (p=0.010) and 5-HT1B genetic polymorphism (p=0.018). Antiandrogen therapy affects T-score (p=0.017), serum phosphorus (p=0.008), glucose (p=0.036) and total proteins (p=0.050). Multivariate-stepwise logistic regression analysis showed the significant association of treated PCa with age (p=0.028) and inorganic phosphorus (p=0.005), and a marginal association with ultrasonographic T-score (p=0.052). Antiandrogen therapy might induce bone mineral loss in elderly PCa patients. Preliminary data imply that the genetic variants of 5-HT1B receptor might be associated with PCa.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

Projekti:
108-1080316-0298 - Molekularna osnova aterogeneze
022-0222411-2407 - Procjena rizika pobola i smrtnosti u populaciji Hrvatske: prospektivna studija (Pavlović, Mladen, MZOS ) ( CroRIS)
022-0222411-2409 - Utjecaj čimbenika iz općeg i radnog okoliša na mišićno-koštani sustav (Cvijetić Avdagić, Selma, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
022-0222411-2409.
022-0222411-2408 - Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca (Pizent, Alica, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Zdravstveno veleučilište, Zagreb,
Dječja bolnica Srebrnjak

Profili:

Sanja Milković-Kraus (autor)