Naslov
Synthesis of novel sulfonamido and 1, 2, 3-triazolyl reversed nucleoside derivatives

Autori
Žinić, Biserka ; Župančić, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book, SEee, Glasgow, Scotland / - Glasgow, 2011, 185-185

Skup
23rd International Congress of Heterocyclic Chemistry (ICHC 2011)

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 31.07.2011. - 04.08.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sulfonamido reversed nucleoside derivatives; 1; 2; 3-triazolyl reversed nucleoside derivatives

Sažetak
Recently, we have prepared a series of novel pyrimidine derivatives possessing a sulfonamide and a nucleobase pharmacophore, which exhibit strong antitumor activity.1, 2 As a part of our program directed toward the synthesis and characterization of biologically active nucleobase derivatives, we decided to synthesized sulfonamido II and 1, 2, 3-triazolyl derivatives III of reversed nucleosides. Based on our reported synthesis of "double headed" nucleosides3, 4 we prepared a series of C-5' substituted reversed nucleosides I. The introduction of the sulfonamido group at the C-1 position of the ribose was achieved using different sulfonamides and boron trifluoride etherate as the catalyst. We have also prepared novel 1, 2, 3-triazolyl reversed nucleoside derivatives III via suitable protected reversed nucleoside intermediates using 1, 4-regioselective copper-catalyzed azide/alkyne cycloaddition (CuAAC). The synthesis of the target nucleoside derivatives will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA