Naslov
Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

Autori
Brčić, Luka ; Brčić, Iva ; Starešinić, Mario ; Novinščak, Tomislav ; Sikirić, Predrag ; Seiwerth, Sven

Izvornik
Journal of physiology and pharmacology (0867-5910) 60 (2009), S7; 191-196

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
angiogenesis; pentadecapeptide BPC 157; cell culture; healing; muscle; tendon; vascular endothelial growth factor

Sažetak
Angiogenesis is a natural and complex process controlled by angiogenic and angiostatic molecules, with a central role in healing process. One of the most important modulating factors in angiogenesis is the vascular endothelial growth factor (VEGF). Pentadecapeptide BPC 157 promotes healing demonstrating particular angiogenic/angiomodulatory potential. We correlated the angiogenic effect of BPC 157 with VEGF expression using in vitro (cell culture) and in vivo (crushed muscle and transected muscle and tendon) models. Results revealed that there is no direct angiogenic effect of BPC 157 on cell cultures. On the other hand, immunohistochemical analysis of muscle and tendon healing using VEGF, CD34 and FVIII antibodies showed adequately modulated angiogenesis in BPC 157 treated animals, resulting in a more adequate healing. Therefore the angiogenic potential of BPC 157 seems to be closely related to the healing process in vivo with BPC 157 stimulating angiogenesis by up-regulating VEGF expression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Rad je prezentiran na skupu 7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organo-protection : Focus on GI Tract, održanom od 09.-11.09.2012., Hawaii.

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