Naslov
Uptake and efflux transporters versus the adme-tox concept in aquatic toxicology

Autori
Smital, Tvrtko ; Žaja, Roko ; Popović, Marta ; Lončar, Jovica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Primo 16 - Pollutant Responses in Marine Organisms

Mjesto i datum
Long Beach (CA), Sjedinjene Američke Države, 14.05.2011. - 18.05.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
uptake transporters ; ABC transport proteins ; ADME-Tox

Sažetak
Traditional thought is that lipophilic chemicals enter cells by passive diffusion. In recent years, however, it is becoming evident that uptake transporters from the SLC (Solute Carrier Class) superfamily play essential role in mediating the entrance of a large number of endo- and xenobiotics into cells. On the other side of the ADME-Tox concept, the efflux activity of ABC (ATP Binding Cassette) transport proteins appears to be one of the most intriguing defense strategies evolutionary developed in aquatic organisms, contributing to the multixenobiotic resistance (MXR) mechanism. As in the mammalian tissues, the complex network of uptake and efflux transporters present in barrier and/or detoxifying tissues of aquatic animals transport a diverse group of xeno- and endobiotics and/or their metabolites in or out of the cell, enabling proper functioning of the cellular detoxification machinery. Furthermore, we do know that the main disadvantage of the ABC transporters is their sensitivity to the presence of specific compounds, termed chemosensitizers or MXR inhibitors. If function of ABC transporter(s) is inhibited, the final consequence is increase in intracellular accumulation and toxicity of xenobiotics normally being effluxed by corresponding transporter(s). Significance of chemosensitization has been additionally supported by inhibitors identified among both conventional and emerging man-made pollutants. Nevertheless, despite their physiological importance and role in cellular detoxification which is a well established concept in mammalian toxicology, the knowledge about uptake and efflux transporters in non-mammalian species is modest, and the topic is still considered relatively exotic in the environmental context. Therefore, in this paper the actual state of knowledge in this area will be briefly summarized, critical research drawbacks highlighted, and potential environmental relevance of this research additionally discussed.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA