Naslov
Effects-directed Analysis of Contaminated Sediments from the Sava River, Croatia

Autori
Ahel, Marijan ; Terzić, Senka ; Lončar, Jovica ; Mikac, Iva ; Žaja, Roko ; Senta, Ivan ; Popović, Marta ; Sauerborn Klobučar, Roberta ; Tollefsen, Knut-Erik ; Thomas, Kevin V ; Smital, Tvrtko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Ecosystem Protection in a Sustainable World: A Challenge for Science and Regulation / - Milano : Society of Environmental Toxicology and Chemistry (SETAC), Europe Office, 2011, 31-31

Skup
SETAC Europe 21st Annual Meeting Ecosystem Protection in a Sustainable World: A Challenge for Science and Regulation

Mjesto i datum
Milano, Italija, 15.05.2011. - 19.05.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
organic contaminants ; effects-directed analysis ; Sava River ; sediment

Sažetak
The application of toxicity identification and evaluation (TIE) protocols for the toxicological characterisation of contaminated sediments showed that the majority of the observed adverse ecological effects were associated with toxic organic chemicals. Considering enormous number as well as chemical and toxicological diversity of organic contaminants, effects-directed analysis (EDA) represents the best available tool for the comprehensive assessment of hazardous chemical contamination in aquatic sediments. The aim of this paper is to present the results obtained in a case study carried out in the Sava River basin, Croatia. The analytical approach used for screening included a detailed characterisation of the collected samples, based on the combination of gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/time-of-flight mass spectrometry (LC/Q-TOF). Ecotoxicity profiling of the investigated samples was performed using a battery of bioassays, including cytotoxicity, chronic toxicity, EROD activity ; inhibition of the multixenobiotic resistance (MXR), genotoxicicity and estrogenic potential. The most pronounced effect, detected in the Sava River sediment, was CYP1A induction potential. It was predominately associated with the nonpolar fraction and polycyclic aromatic hydrocarbons were indicated to be responsible for the observed effect. However, other endpoints, such as algal toxicity and estrogenic potential, indicated comparatively higher importance of polar contaminants.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Biologija

POVEZANOST RADA