Naslov
Magnesium in leukocytes and plasma of asthmatic children

Autori
Novak Mirčetić ; , Renata ; Čepelak, Ivana ; Ibrahimi, Suzana ; Raos, Miljenko ; Dodig, Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine; Special Supplement, Abstracts Volume / Siest, Gerard ; Dominiczak, Marek H - Berlin : New York : Walter de Gruyter, 1999

Skup
IFCC-WorldLab, 17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Magnesium; leukocytes; plasma; asthma

Sažetak
Mg2+is a co-factor in more than 325 enzymes systems in cells and is the second most abundant intracellular cation. It is important in numerous physiological functions among others muscle contraction. Mg2+ acts as smooth muscle relaxator and Ca-canals blocker in vitro. We decided to test changes of total Mg2+ concentration in plasma and in leukocytes of 16 healthy children and 26 patients with bronchoopstruction ageing 3 to 14 years. The samples were taken at first day of bronchoopstruction and five days after the acute attack. During these period children were under therapy with salbutamol. Plasma Mg2+ concentration increase for about 40 % in patients (first day 0.60„b0.035 mmol/L and five days later 0.62„b0.023 mmol/L) when compared to the healthy children (0.44„b0.041 mmol/L). However, leukocyte Mg2+ concentration showed significant changes. At first day of bronchoopstruction Mg2+ in leukocytes statistically decreased (about 70%) in patients (1.16„b0.31 mmol/g prot.) towards the healthy children (3.42„b0.92 mmol/g prot). Five days later Mg2+ values in leukocytes statistically increased (3.28„b1.09 mmol/g prot) and almost reach the values in healthy group. The results obtained indicate that determination of Mg2+ concentration in leukocytes could be used in the assessment of asthmatic pathology.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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