Naslov
Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes.

Autori
Boraska, Vesna ; Rayner, N.W. ; Groves, C.J. ; Frayling, T.M. ; Diakite, M. ; Rockett, K.A. ; Kwiatkowski, D.P. ; Day-Williams, A.G. ; McCarthy, M.I. ; Zeggini, E.

Izvornik
BMC medical genetics (1471-2350) 11 (2010); 69-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
T2D; TNF/LTA gene; tag SNPs; case-control study; family based study; association

Sažetak
The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of association. The purpose of this study is to examine T2D association of tag SNPs in the TNF/LTA region capturing the majority of common variation in a large-scale sample set of UK/Irish origin. This study comprised a case-control (1520 cases and 2570 control samples) and a family-based component (423 parent-offspring trios). Eleven tag SNPs (rs928815, rs909253, rs746868, rs1041981 (T60N), rs1800750, rs1800629 (G- 308A), rs361525 (G-238A), rs3093662, rs3093664, rs3093665, and rs3093668) were selected across the TNF/LTA locus and genotyped using a fluorescence-based competitive allele specific assay. Quality control of the obtained genotypes was performed prior to single- and multi-point association analyses under the additive model. We did not find any consistent SNP associations with T2D in the case-control or family-based datasets. The present study, designed to analyse a set of tag SNPs specifically selected to capture the majority of common variation in the TNF/LTA gene region, found no robust evidence for association with T2D. To investigate the presence of smaller effects of TNF/LTA gene variation with T2D, a large-scale meta-analysis will be required.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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