Naslov
Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium

Autori
Ćurčić, Marijana ; Stanković, Sanja ; Jaćević, Vesna ; Janković, Saša ; Durgo, Ksenija ; Milovanović, Vesna ; Vučinić, Slavica ; Antonijević, Biljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
TOXICOLOGY LETTERS / Kehrer, J.P. - Pariz : Elsevier, 2011, 210-211

Skup
47th Congress of the European Societies of Toxicology (EUROTOX)

Mjesto i datum
Pariz, Francuska, 28.08.2011. - 31.08.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
rats; liver enzyme; BDE209; cadmium

Sažetak
During the last ten years, mixture toxicology has undergone a remarkable and productive development. Mixture of decabromodiphenyl ether (BDE209) and cadmium (Cd) was chosen in this study based on the data that BDE209 from the group of persistant organic pollutants and Cd from the group of heavy metal pollutants are most abundant in human samples. Aim of this study was to evaluate whether simultaneous exposure to BDE 209 and Cd can influence deviation from response obtaned during single exposure. Wistar rats (~200-240 g) were exposed orally, by gavage, for 28 days to the 3 doses of BDE 209 (1000, 2000 and 4000 mg/kg/bw, respectively) and to single dose of Cd (2, 5 mg/kg/bw), as well as to 3 groups of combination of each dose of BDE209 and Cd. Control groups were also included in experiment, one where DMSO was administered as a vehiculum, and control group withouth any treatment (totally 9 groups). Liver enzymes activities (aspartate aminotransferase-AST, alanine aminotransferase-ALT and γ-glutamyltransferase-γ-GT) were measured as a result of effects of investigated contaminants. Combination of BDE209 and Cd do not influence activity of AST and ALT obtained during exposure to the both contaminants separately. On the other hand, activity of γ-GT was impaired, but only in combination of lowest dose of BDE209 and Cd comparing with group exposed onl yto the BDE 209. Enzymes activities did not follow dose dependent manner. We suppose that the results of histlogical examination will give better explanation. And also we will continue with further investigation on other target organ toxicity of this mixture.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA