Naslov
Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats

Autori
Ćurčić, Marijana ; Jaćević, Vesna ; Stanković, Sanja ; Janković, Saša ; Durgo, Ksenija ; Vučinić, Slavica ; Antonijević, Biljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
TOXICOLOGY LETTERS / Kehrer, J.P. - Pariz : Elsevier, 2011, 211-211

Skup
47th Congress of the European Societies of Toxicology (EUROTOX)

Mjesto i datum
Pariz, Francuska, 28.08.2011. - 31.08.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BDE 209; cadmium; thyroid; in vivo; rats

Sažetak
Polybrominated diphenyl ethers (PBDEs) are structurally similar to thyroid hormones and can affect thyroid hormone homeostasis. Simultaneous exposure to PBDEs and heavy metals, specially Cd is likely to occur under real life conditions. Therefore, we have investigated the potential thyroid hormones level effects following 28 day long oral aplication of mixture of decabromodiphenyl ether (BDE209) and cadmium (Cd) in male Wistar rats (~200-240 g). Animals were divided in totally 9 groups (6 to 8 in each): control group, vehiculum (DMSO) group, groups of BDE 209 (1000, 2000 and 4000 mg/kg/bw, respectively) and three groups of combination of each dose of BDE209 and Cd. Total serum tetraiodothyronine (T4) was significantly reduced in all groips comparing with control. Total serum triiodothyronine (T3) was significantly decreased only in groups treated with combinations of BDE209 and Cd comparing with control. Free T3 and T4 have showed decrease at the certain doses not related with any dose dependent manner. Thyroid stimulating hormone (TSH) could not be measured because of disturbance of laboratory analyser. Results indicates that BDE209 affect thyroid hormon homeostasis, but observing the results of effects of mixture of this chemical with Cd, we can not conclude how Cd influence BDE 209 thyroid toxicity at this low dose exposure level of 2, 5 mg/kg/bw. Coming results where combinations of BDE209 with higher doses of Cd may reveal possible interection.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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