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Pregled bibliografske jedinice broj: 542991

Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity

Domijan, Ana-Marija; Abramov, Andrey, Y.
Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity // International journal of biochemistry & cell biology, 43 (2011), 6; 897-904 doi:10.1016/j.biocel.2011.03.003 (međunarodna recenzija, članak, znanstveni)

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Naslov
Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity

Autori
Domijan, Ana-Marija ; Abramov, Andrey, Y.

Izvornik
International journal of biochemistry & cell biology (1357-2725) 43 (2011), 6; 897-904

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ca2+ signalling; mitochondria; mycotoxins; neurotoxicity; reactive oxygen species

Sažetak
Fumonisin B1 (FB1) is a neurodegenerative mycotoxin produced by Fusarium verticiloides mould that contaminates maize worldwide. FB1 toxicity has been connected with deregulation of sphingolipid metabolism, but the mechanism of cytotoxicity remains controversial. In cell cultures of rat primary astrocytes and human neuroblastoma (SH-SY5Y), we found that FB1 inhibits mitochondrial complex I, which leads to a decrease in the rate of mitochondrial and cellular respiration, depolarisation of the mitochondrial membrane, induction of reactive oxygen species (ROS) production in mitochondria and deregulation of calcium signalling. Despite the increase in ROS production, the intracellular level of glutathione (GSH) was significantly increased. After 24 h of FB1 exposure, no cell death was observed. Thus, mitochondria appear to be the primary target of FB1, which leads to sustained deregulation of calcium homeostasis and presumably to cell death.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
022-0222148-2142 - Toksični učinci mikotoksina na ljude i životinje (Peraica, Maja, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Ana-Marija Domijan (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com ac.els-cdn.com dx.doi.org

Citiraj ovu publikaciju:

Domijan, Ana-Marija; Abramov, Andrey, Y.
Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity // International journal of biochemistry & cell biology, 43 (2011), 6; 897-904 doi:10.1016/j.biocel.2011.03.003 (međunarodna recenzija, članak, znanstveni)
Domijan, A. & Abramov, Andrey, Y. (2011) Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity. International journal of biochemistry & cell biology, 43 (6), 897-904 doi:10.1016/j.biocel.2011.03.003.
@article{article, author = {Domijan, Ana-Marija}, year = {2011}, pages = {897-904}, DOI = {10.1016/j.biocel.2011.03.003}, keywords = {Ca2+ signalling, mitochondria, mycotoxins, neurotoxicity, reactive oxygen species}, journal = {International journal of biochemistry and cell biology}, doi = {10.1016/j.biocel.2011.03.003}, volume = {43}, number = {6}, issn = {1357-2725}, title = {Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity}, keyword = {Ca2+ signalling, mitochondria, mycotoxins, neurotoxicity, reactive oxygen species} }
@article{article, author = {Domijan, Ana-Marija}, year = {2011}, pages = {897-904}, DOI = {10.1016/j.biocel.2011.03.003}, keywords = {Ca2+ signalling, mitochondria, mycotoxins, neurotoxicity, reactive oxygen species}, journal = {International journal of biochemistry and cell biology}, doi = {10.1016/j.biocel.2011.03.003}, volume = {43}, number = {6}, issn = {1357-2725}, title = {Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity}, keyword = {Ca2+ signalling, mitochondria, mycotoxins, neurotoxicity, reactive oxygen species} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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