Naslov
Bicuspid aortophaty – pathophysiology and clinical implications.
(Bicuspid aortophaty – pathophysiology and clinical implications)

Autori
Ružić, Alen, Raljević, Damir, Peršić, Viktor, Pehar-Pejčinović, Vesna, Miletić, Bojan, Laškarin, Gordana, Ivančić-Vagaja Suzana.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book / - Novi Sad, 2009, 63-63

Skup
1st International symposium of clinical and applied anatomy

Mjesto i datum
Novi Sad, Srbija, 17.09.2009. - 19.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bicuspid aortic valve

Sažetak
Background and aims: The bicuspid aortic valve (BAV) is the most common congenital lesion affecting the human heart which is associated with abnormalities of the ascending aorta and increased risk for aortic complication. The etiology of aortic changes in BAV remains controversial, although evidence indicate intrinsic pathology appears to be responsible for aortic enlargement beyond that induced by hemodynamic factors. It seems that the same defect affects not only the aortic valve, but also the wall of the aorta itself. The aim of this study is to review the BAV-associated aortophaty with special emphasis on the etiology and directions for further trails and investigations. Methods: Systemic literature review. Results: Patients with BAV require continuous surveillance to prevent, identify and treat complications. The further improvement in clinical practice at these point dependents mostly on the final definition of the etiology pathway in aorthopathy progression and complications development. According to the literature, defect in collagen metabolism, anomalous behavior of cells derived from the neural crest and abnormalities of endothelial nitric oxide syntheses during organogenesis, as well as the process of extracellular aortic wall matrix remodeling with metalloproteinase activity and apoptosis of vascular smooth muscle cells, need to be further investigated. Conclusion: There is a wide spectrum of ascending aortic dilatation and acute aortic complications in BAV. The mechanism triggering their development should b investigated intensively for further improvement in prediction, screening, prevention and mechanical treatment of those patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA