Pregled bibliografske jedinice broj: 542348
Neurochemical and Behavioural Changes in Rat Models of Depression
Neurochemical and Behavioural Changes in Rat Models of Depression // Croatica chemica acta, 84 (2011), 2; 287-299 doi:10.5562/cca1817 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 542348 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Neurochemical and Behavioural Changes in Rat Models of Depression
Autori
Skelin, Ivan ; Kovačević, Tomislav ; Dikšić, Mirko
Izvornik
Croatica chemica acta (0011-1643) 84
(2011), 2;
287-299
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders
Sažetak
Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/ biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model ; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
219-1081870-2032 - Serotoninski receptori te promjena antidepresivima u štakorskom modelu depresije (Dikšić, Mirko, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
