Naslov
A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice

Autori
Casós, Kelly ; Zaragozá, María C. ; Žarković, Neven ; Žarković, Kamelija ; Andrišić, Luka ; Portero-Otín, Manuel ; Cacabelo, Daniel ; Mitjavil, María T.

Izvornik
Free radical research (1071-5762) 44 (2010), 7; 821-829

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atherosclerosis; 4-hydroxynonenal; polyunsaturated fatty acids; nitric oxide; superoxide anion; aortic root

Sažetak
Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE–/– mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O2.–) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22phox expression and O2.–production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.

Izvorni jezik
Engleski

POVEZANOST RADA