Naslov
Inflammatory and neuroprotective proteins in the thalamus following traumatic brain injury in the rat

Autori
Pilipović, Kristina ; Župan, Željko ; Župan, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Osredkar, D. ; Koritnik, B. ; Pelko, M. - Ljubljana : Neuroscience Association, 2011, 142-142

ISBN
978-961-91704-4-1

Skup
SiNAPSA Neuroscience Conference ´11

Mjesto i datum
Ljubljana, Slovenija, 22.09.2011. - 25.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thalamus; inflammation; neuroprotection; traumatic brain injury; rat
(traumatic brain injury; thalamus; inflammation; neuroprotection; rat)

Sažetak
Thalamus is the brain region whose damage has been well documented after both human and experimental traumatic brain injury (TBI). Molecular mechanisms which lead to posttraumatic cell death or support the neuronal survival in the thalamus, in this entity, have not yet been fully characterized. Therefore, aim of this study was to determine the changes in several markers of inflammation and also cell protection following experimental TBI in the rat. Experiments were carried out on adult male rats. TBI of moderate severity was performed over the left parietal cortex using the lateral fiuid percussion brain injury model. Sham-operated animals were used as the control group. Rats were sacrificed 24 h after the TBI induction and the thalami were processed for the Western blot analyses of different protein expressions. TBI caused significant increases of the cyclooxygenase-2, inducible nitric oxide synthase and heat shock protein 70 expressions in the thalamus of rats with TBI in relation to the values registered in sham-operated animals. Thalamic expressions of inhibitory kappa B alpha and brain derived neurotrophic factor were unaffected by TBI in our experimental conditions.

Izvorni jezik
Engleski

POVEZANOST RADA