Naslov
Serum levels of metalloproteinases and their inhibitors during the infection with pathogens having integrin-receptors mediated cellular entry

Autori
Cvetko Krajinović, Lidija ; Šoprek, Silvija ; Korva, Miša ; Dželalija, Boris ; Đaković Rode, Oktavija ; Škerk, Višnja ; Avšič Županc, Tatjana ; Markotić, Alemka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts - 2011 Annual Meeting of the Croatian Immunological Society / - , 2011

Skup
2011 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Rabac, Hrvatska, 07.10.2011. - 09.10.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Matrix metalloproteinases; integrin receptors; Dobrava virus; Coxiella burnetii; Escherichia coli

Sažetak
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes whose numerous roles are found in the normal immune response to infection. However, excess MMP activity following infection may lead to immunopathological processes that cause tissue damage. Expression, secretion, and activity of MMPs in normal tissues are subject to tight control which is regulated by its specific endogenous tissue inhibitors (TIMPs). It is known that MMPs bind to cell surface proteins (e.g. integrin receptors), and such interactions can have modulatory effects on MMP functionality. The objective of this study was to test whether there are some differences in MMP and TIMP production during the acute infection with different pathogens using β integrins as their receptors for the cell entry. We measured total amounts of soluble MMP-2, MMP-9, TIMP-1, and TIMP-2 in the sera from patients infected with Dobrava virus (DOBV) and Coxiella burnetii (representatives of β3 integrin cell entry) or uropathogenic Escherichia coli (representative of β1 integrin cell entry). Statistical analyses were used to correlate MMP/TIMP serum levels with different biochemical parameters. The results showed that both bacterial infections generally manifested the stronger effect on MMPs production while, in contrast, viral infection introduced stronger changes on metalloproteinase inhibitors. MMPs and TIMPs significantly correlated with some of biochemical parameters in both bacterial infections but no correlations were found in DOBV infection. This could suggest diverse mechanisms by which MMP activity could be implicated in pathology of these two bacterial infections versus viral, DOBV infection despite their cellular entry receptors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA