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Pregled bibliografske jedinice broj: 541791

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis

Golomb, L.; Bublick. D.R.; Wilder, S.; Nevo, R.; Kiss, Vladimir; Grabušić, Kristina; Volarević, Siniša; Oren, M.
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis // Molecular cell, 45 (2012), 2; 222-232 doi:10.1016/j.molcel.2011.11.022 (međunarodna recenzija, članak, znanstveni)

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Naslov
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis

Autori
Golomb, L. ; Bublick. D.R. ; Wilder, S. ; Nevo, R. ; Kiss, Vladimir ; Grabušić, Kristina ; Volarević, Siniša ; Oren, M.

Izvornik
Molecular cell (1097-2765) 45 (2012), 2; 222-232

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ribosome biogenesis; p53; c-Myc

Sažetak
Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, required for ribosome biogenesis. We report that transcription of the genes encoding the β-karyopherins importin 7 (IPO7) and exportin 1 (XPO1) and several additional proteins involved in nuclear import, is regulated positively by c-Myc and negatively by p53. Partial depletion of IPO7 leads to p53 activation and p53-dependent growth arrest. Activation of p53 by IPO7 knockdown has distinct features of ribosomal biogenesis stress, with increased binding of Mdm2 to ribosomal proteins L5 and L11 (RPL5 and RPL11). Furthermore, p53 activation is dependent on RPL5 and RPL11. Of note, IPO7 and XPO1 are frequently overexpressed in cancer. Altogether, we propose that c-Myc and p53 counter each other in the regulation of elements within the nuclear transport machinery, thereby exerting opposing effects on the rate of ribosome biogenesis. Perturbation of this balance may play a significant role in promoting cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-1081347-0370 - Odgovor stanica sisavaca na pogrešku u sintezi ribozoma in vivo (Volarević, Siniša, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Siniša Volarević (autor)

Avatar Url Kristina Grabušić (autor)

Poveznice na cjeloviti tekst rada:

doi ac.els-cdn.com www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Golomb, L.; Bublick. D.R.; Wilder, S.; Nevo, R.; Kiss, Vladimir; Grabušić, Kristina; Volarević, Siniša; Oren, M.
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis // Molecular cell, 45 (2012), 2; 222-232 doi:10.1016/j.molcel.2011.11.022 (međunarodna recenzija, članak, znanstveni)
Golomb, L., Bublick. D.R., Wilder, S., Nevo, R., Kiss, V., Grabušić, K., Volarević, S. & Oren, M. (2012) Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Molecular cell, 45 (2), 222-232 doi:10.1016/j.molcel.2011.11.022.
@article{article, author = {Golomb, L. and Wilder, S. and Nevo, R. and Kiss, Vladimir and Grabu\v{s}i\'{c}, Kristina and Volarevi\'{c}, Sini\v{s}a and Oren, M.}, year = {2012}, pages = {222-232}, DOI = {10.1016/j.molcel.2011.11.022}, keywords = {ribosome biogenesis, p53, c-Myc}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2011.11.022}, volume = {45}, number = {2}, issn = {1097-2765}, title = {Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis}, keyword = {ribosome biogenesis, p53, c-Myc} }
@article{article, author = {Golomb, L. and Wilder, S. and Nevo, R. and Kiss, Vladimir and Grabu\v{s}i\'{c}, Kristina and Volarevi\'{c}, Sini\v{s}a and Oren, M.}, year = {2012}, pages = {222-232}, DOI = {10.1016/j.molcel.2011.11.022}, keywords = {ribosome biogenesis, p53, c-Myc}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2011.11.022}, volume = {45}, number = {2}, issn = {1097-2765}, title = {Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis}, keyword = {ribosome biogenesis, p53, c-Myc} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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