Naslov
Carcinogenic mycotoxins

Autori
Domijan, Ana-Marija ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Carcinogens, Vol 14.

Urednik/ci
Charlene A. McQueen

Izdavač
Elsevier

Grad
Oxford

Godina
2010

Raspon stranica
125-137

ISBN
9780080468846

Ključne riječi
AFB1-albumin adduct, AFB1-DNA adduct, aflatoxins, endemic nephropathy, epigenetic mechanism, esophageal cancer, fumonisins, hepatocelular carcinoma, neural tube defect, ochratoxins, oxidative stress, sphingolipids

Sažetak
Mycotoxins are natural contaminants of different commodities and human exposure to mycotoxins canno be avoided. Mycotoxin aflatoxin B1 (AFB1) is confirmed as a human carcinogen, while some other mycotoxins, such as fumonisin Bq (FB1) and ochratoxin A (OTA), are carcinogenic in experimental animals but the proof of carcinogenicity of FB1 and OTA are not known. However, studies of their mechanims of carcinogenicity showd that epigenetic effects are likely to be involved. Research on experimental animals and legislation is focused on exposure to a single mycotoxin, a situation is that rarely occurs in natural conditions. Various combinations of mycotoxins could give rise to synergistic toxic effect and promte their carciongenicity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA