Naslov
Meningiomas: role of genetic instabilities of the E-cadherin gene

Autori
Pećina Šlaus, Nives

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Tumors of the central nervous system

Urednik/ci
Hayat, M.A.

Izdavač
Springer

Grad
Heidelberg

Godina
2012

Raspon stranica
95-98

ISBN
978-94-007-2893-6

Ključne riječi
E-cadherin, meningioma

Sažetak
The numerous reports by many authors as well as our own results indicate that E-cadheirn plays a role in CNS tumors - meningiomas. The suppression of E-cadherin expression is regarded as one of the main molecular events responsible for dysfunction in cell-cell adhesion. It is now apparent that downregulation of E-cadherin expression is involved in meningioma development. Our studies on meningiomas of different grades showed that 73% of meningiomas had downregulation of E-cadherin expression. Intense downregulation was noticed in tumors with grades II and III. Our analysis on the genetic level of E-cadherin changes showed loss of heterozygosity (LOH) in 32% meningiomas investigated. Also, another type of genomic instability was detected in 11% of our sample ¾ MSI phenotype. The instability is the result of impaired cellular mismatch repair. Beta-catenin is the main effector molecule in wnt signaling and is bound to E-cadherin in adherens junctions. Beta-catenin was progressively upregulated from meningothelial to atypical, while 60% of anaplastic showed upregulation and nuclear localization of the protein. A significant association between the genetic changes of CDH1 and the nuclear localization of beta-catenin protein (P<0.022) was established in our study. Better understanding of meningioma genetic profile will elucidate pathophysiological mechanisms of tumor formation, and eventually offer improved prognostic markers for meningioma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA