Naslov
Spray dried microparticles for controlled delivery of mupirocin calcium : Process–tailored modulation of drug release

Autori
Dűrrigl, Marjana ; Kwokal, Ana ; Hafner, Anita ; Šegvić Klarić, Maja ; Dumičić, Aleksandra ; Cetina-Čižmek, Biserka ; Filipović-Grčić, Jelena

Izvornik
Journal of microencapsulation (0265-2048) 28 (2011), 2; 108-121

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mupirocin calcium; spray drying; solid dispersions; controlled release

Sažetak
Spray dried microparticles containing mupirocin calcium were designed as acrylic matrix carriers with modulated drug release for efficient local drug delivery at minimum daily dose. Particle generation in spray drying and its effect on release performance were assessed by varying drug : polymer ratios with consequently altered initial saturations. Narrow-sized microparticles with mean diameters of 1.7–2.5 mm were obtained. Properties of the generated solid dispersions were examined by X-ray, thermal (thermogravimetric analysis, modulated differential scanning calorimetry) and spectroscopic (Fourier transformed infrared, Fourier transformed Raman) methods and correlated with drug loading and in vitro release. The best control over mupirocin release was achieved for 2 : 1 (w/w) drug : polymer ratio and found to be strongly process-dependent. For a particular ratio, increased feed concentration (44%) boosted while increased inlet temperature reduced drug release. Antimicrobial activity testing confirmed that encapsulated drug preserved its antibacterial effectiveness. Conclusively, spray drying was proven as a suitable method for preparing structured microparticles which can control drug release even at exceptionally high drug loadings.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA