Naslov
Perinatal mortality and congenital malformations in offspring of pregestational diabetic mothers in Croatia

Autori
Đelmiš, Josip ; Ivanišević, Marina ; Juras, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
41st Annual meeting of DPSG / DPSG - Frascati : DPSG, 2009, 31-31

Skup
41st Annual meeting of DPSG

Mjesto i datum
Frascati, Italija, 25.09.2009. - 28.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
perinatal mortality; congenital malformations; offspring; diabetes; Croatia

Sažetak
Background. Pregnant women with type 1 and type 2 diabetes mellitus are associated with an increased risk of congenital malformations, perinatal mortality, obstetric complications, and neonatal morbidity. Methods. We analyzed perinatal outcomes and the incidence of congenital malformations in offspring of type 1 and type 2 diabetic mothers from 1993 until 2008 years divided in the two periods. The aim of the study was to examine the cases of type 1 and type 2 diabetic mothers during the two periods 1993. - 2000 (the first period) and 2001- 2008 (the second period) recorded by EUROCAT of Congenital Malformations. Results. In the first period there were 228 births after where the mother had type 1 diabetes and 12 births where the mother had type-2 diabetes. In the second period there were 277 births after a pregnancy where the mother had type 1 diabetes and 69 births where the mother had type-2 diabetes. In the second period there were statistically significant higher number of deliveries by type 2 diabetic mothers (p<o.ooi). Perinatal mortality in the second period was statistically significant lower than in the second period (1.2%: 4.6% ; p<o.os). Incidence of congenital malformations did not different between two periods (5% : 6.4% ; n.s.). Thirty-four (5.8%) malformations were identified. In the group of type 1 diabetic mothers there were 28 (5.54%) malformations, and in the group of type 2 diabetic mothers there were 6 (7.4%) malformed cases. Perinatal mortality in the group of malformed cases was 17.4% (6 cases ; 2 stillbirths and 4 neonatal mortality). The types of malformations identified were: cardiovascular (17) ; musculoskeletal (4) ; urinary (7) ; CNS (2) ; gastrointestinal (3) ; multiple malformation (1). Significantly higher rate of obesity (BMI 22.713.4:25.9+4.6 ; p<0.05) and older maternal age (28.613.5:31.914.5 ; p<o.o5) was observed in diabetic mothers of malformed cases. The incidence of congenital malformations are related to periconceptional care, especiallythe level ofglycemiccontrol (HbAic 7.211.8:9.8+1.6 ; pco.ooi). Conclusion: In the second research period in offspring of pregestational diabetic mothers perinatal mortality significantly decreased. Adequate preconceptional care reduces the frequency of congenital malformations and improves outcome of pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA