A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)

Krištafor, Svjetlana; Novaković, Ivana; Gazivoda Kraljević, Tatjana; Kraljević Pavelić, Sandra; Lučin, Pero; Westermaier, Yvonne; Pernot, Lucile; Scapozza, Leonardo; Ametamey, Simon M.; Raić-Malić, Silvana

doi:10.1016/j.bmcl.2011.07.115

Pregled bibliografske jedinice broj: 538174

A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)

Krištafor, Svjetlana; Novaković, Ivana; Gazivoda Kraljević, Tatjana; Kraljević Pavelić, Sandra; Lučin, Pero; Westermaier, Yvonne; Pernot, Lucile; Scapozza, Leonardo; Ametamey, Simon M.; Raić-Malić, Silvana

A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK) // Bioorganic & medicinal chemistry letters, 21 (2011), 20; 6161-6165 doi:10.1016/j.bmcl.2011.07.115 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 538174 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)

Autori
Krištafor, Svjetlana ; Novaković, Ivana ; Gazivoda Kraljević, Tatjana ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Westermaier, Yvonne ; Pernot, Lucile ; Scapozza, Leonardo ; Ametamey, Simon M. ; Raić-Malić, Silvana

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 21 (2011), 20; 6161-6165

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
6-(1, 3-Dihydroxyisobutenyl)thymine ; herpes simplex virus type 1 thymidine kinase (HSV-1 TX) ; molecular docking ; positron emission tomography (PET)

Sažetak
Molecular modeling and phosphorylation assay in vitro were employed to select a novel unsaturated 1, 3-dihydroxyisobutenyl thymine derivative 6 as ligand for HSV-1 TK which may be of interest as lead for the development of an positron emission tomography (PET) imaging agent. Compound 6 was successfully prepared using modified approaches. A significant improvement over the syntheses involving pathways A and B (1% and 3% overall yield, respectively), was observed using synthetic route C (14% overall yield).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
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