Naslov
Prognostic significance of survivin and caspase-3 immunohistochemical expression in patients with diffuse large B-cell lymphoma treated with rituximab and CHOP

Autori
Mitrović, Zdravko ; Ilić, Ivana ; Aurer, Igor ; Bašić-Kinda, Sandra ; Radman, Ivo ; Dotlić, Snježana ; Ajduković, Radmila ; Labar, Boris

Izvornik
Pathology oncology research (1219-4956) 17 (2011), 2; 243-247

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
non-Hodgkin's lymphoma; diffuse large B-cell lymphoma; survivin; caspase-3; prognostic factors; rituximab; immunohistochemistry
(non-Hodgkin's lymphoma; diffuse large B-cell lymphoma; survivin; caspase-3; prognostic factors; rituximab; immunohistochemistry .)

Sažetak
Survivin is an inhibitor of apoptosis whose expression may be associated with inferior outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated without rituximab. Caspase-3 (CPP32) is the final caspase of the apoptotic cascade and its pattern of expression may also be related to patients’ outcome. In this study we investigated immunohistochemical expression of survivin and caspase-3 in 57 patients with DLBCL treated with rituximab and CHOP (R-CHOP). According to previously published criteria, we separately analyzed correlation of different types of survivin expression with patients’ outcome. Nuclear survivin was expressed in only 26% of cases, cytoplasmic survivin was expressed in 81% of cases while application of immunoreactivity scoring system yielded 58% of survivin positive cases. Caspase-3 was expressed in 77% of cases. There were no significant correlations between any type of survivin expression and response to treatment or survival of the patients. The expression of caspase-3 was also not associated with patients’ outcome. We conclude that survivin and caspase-3 have no significant prognostic significance in patients with DLBCL treated with R-CHOP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA