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Pregled bibliografske jedinice broj: 537563

Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study

Sato, Hiroki; Skelin, Ivan; Dikšić, Mirko
Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study // Neurochemistry international, 58 (2011), 7; 759-766 doi:10.1016/j.neuint.2011.02.024 (međunarodna recenzija, članak, znanstveni)

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Naslov
Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study

Autori
Sato, Hiroki ; Skelin, Ivan ; Dikšić, Mirko

Izvornik
Neurochemistry international (0197-0186) 58 (2011), 7; 759-766

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
flinders sensitive line; genetic animal-model; brain 5-HT synthesis; antidepressant treatment; in-vivo; dopamine release; tryptophan concentration; synthesis invivo; citalopram; receptors

Sažetak
It has been suggested that 5-HT (serotonin ; 5-hydroxytryptamine) and/or the norepinephrine receptor adaptive processes in the brain are the basis for the efficacy of antidepressant treatments, including electro-convulsive shock therapy. In the present study, the effect of acute (10 mg/kg ; i.p. injection) and chronic (10 mg/kg/day ; delivered by subcutaneous mini-pump) desipramine treatments on regional 5-HT synthesis were evaluated in the Flinders Sensitive Line (FSL ; "depressed" rats), as well as the control Flinders Resistant Line (FRL), of rats, using alpha-[(14)C]methyl-L-tryptophan autoradiography. The control rats in each of the strains received the same volume (volume in which drug was dissolved) of saline (whether through an injection or, in the case of the chronic experiments, via an osmotic mini-pump), while the treated rats received desipramine (DMI) dissolved in saline (again, as an i.p. injection or by osmotic mini-pump). The rats were randomly assigned to different groups. The results indicate that acute treatment produces a reduction in regional 5-HT synthesis in both the FSL and FRL rats, while chronic treatment produces an elevation of regional 5-HT synthesis in both strains, but the effect was somewhat greater in the FRL rats. When comparing these results to those of normal Sprague-Dawley rats, our results suggest that it is more informative to study 5-HT synthesis in an animal model of depression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
219-1081870-2032 - Serotoninski receptori te promjena antidepresivima u štakorskom modelu depresije (Dikšić, Mirko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mirko Dikšić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Sato, Hiroki; Skelin, Ivan; Dikšić, Mirko
Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study // Neurochemistry international, 58 (2011), 7; 759-766 doi:10.1016/j.neuint.2011.02.024 (međunarodna recenzija, članak, znanstveni)
Sato, H., Skelin, I. & Dikšić, M. (2011) Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study. Neurochemistry international, 58 (7), 759-766 doi:10.1016/j.neuint.2011.02.024.
@article{article, author = {Sato, Hiroki and Skelin, Ivan and Dik\v{s}i\'{c}, Mirko}, year = {2011}, pages = {759-766}, DOI = {10.1016/j.neuint.2011.02.024}, keywords = {flinders sensitive line, genetic animal-model, brain 5-HT synthesis, antidepressant treatment, in-vivo, dopamine release, tryptophan concentration, synthesis invivo, citalopram, receptors}, journal = {Neurochemistry international}, doi = {10.1016/j.neuint.2011.02.024}, volume = {58}, number = {7}, issn = {0197-0186}, title = {Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study}, keyword = {flinders sensitive line, genetic animal-model, brain 5-HT synthesis, antidepressant treatment, in-vivo, dopamine release, tryptophan concentration, synthesis invivo, citalopram, receptors} }
@article{article, author = {Sato, Hiroki and Skelin, Ivan and Dik\v{s}i\'{c}, Mirko}, year = {2011}, pages = {759-766}, DOI = {10.1016/j.neuint.2011.02.024}, keywords = {flinders sensitive line, genetic animal-model, brain 5-HT synthesis, antidepressant treatment, in-vivo, dopamine release, tryptophan concentration, synthesis invivo, citalopram, receptors}, journal = {Neurochemistry international}, doi = {10.1016/j.neuint.2011.02.024}, volume = {58}, number = {7}, issn = {0197-0186}, title = {Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study}, keyword = {flinders sensitive line, genetic animal-model, brain 5-HT synthesis, antidepressant treatment, in-vivo, dopamine release, tryptophan concentration, synthesis invivo, citalopram, receptors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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