Naslov
Stereology of the rat placenta in the last trimester of gestation

Autori
Vrsaljko, Nina ; Žunić, Iris ; Šerman, Ljiljana ; Grbeša, Đurđica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
21st Ljudevit Jurak International Symposium on Comparative Pathology / Krušlin, Božo ; Čupić, Hrvoj - Zagreb, 2010, 17-18

Skup
21st Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 04.11.2010. - 05.11.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
placenta ; rat ; labyrinth ; decidua

Sažetak
Because of numerous roles of the placenta in fetal period, it is important to understand its development and structure, and due to similarities with the human placenta, rat is an appropriate experimental model. Animals were sacrificed on 16th or 19th day of gestation. The uterus was removed, placentas were isolated, fixed in 10% formalin and a complete series of histological sections of 10 m thickness was made. 35 rat placentas were collected, 21 in the experimental group of 16th and 14 in the experimental group of 19th day of gestation. Three randomly selected placentas from each group were stereologically analyzed. Absolute volumes of placentas and their compartments (labyrinth, basal portion and the decidua) were estimated. Using volume density, we calculated the share of glycogen cells and trophoblast giant cells (TGC) in the basal part of the placenta. The average absolute volume of the placenta on 16th day of gestation is 0.064 cm3, from which a labyrinth makes 0.027 cm3, basal part 0.027 cm3, and decidua 0.009 cm3. The average absolute volume of the placenta on 19th day of gestation is 0.163 cm3, of which the labyrinth makes 0.0923 cm3, basal part 0.059 cm3 and decidua 0.011 cm3. In the 16th day of gestation, volume density of TGC in the basal layer is higher (0.174) in comparisson with 19th day of gestation (0.107). The volume density of glycogenic cells is 0.379 on the 16th day and 0.236 on the 19th day of gestation. We can conclude that the absolute volume of the whole placenta on 19th day of gestation significantly increased, as well as the share of the labyrinth as the most important part. The volume densities of glycogenic and giant trophoblast cells are higher on the 16th day of gestation compared to the 19th day, because the 19th day marks the time when the trophoblast invasion is finished and the definitive placenta is formed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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