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Pregled bibliografske jedinice broj: 537350

RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition

Markiewicz, Mary A.; Wise, Erica L.; Buchwald, Zachary S.; Pinto, Amelia K.; , Zafirova, Biljana; Polić, Bojan; Shaw, Andrey .
RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition // Immunity, 36 (2012), 1; 132-141 doi:10.1016/j.immuni.2011.11.014 (međunarodna recenzija, članak, znanstveni)

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Naslov
RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition

Autori
Markiewicz, Mary A. ; Wise, Erica L. ; Buchwald, Zachary S. ; Pinto, Amelia K. ; , Zafirova, Biljana ; Polić, Bojan ; Shaw, Andrey .

Izvornik
Immunity (1074-7613) 36 (2012), 1; 132-141

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
T cells; NKG2D; pancreatic islets; Rae1; insulitis

Sažetak
The mechanisms by which CTLs enter and are retained in non-lymphoid tissue are not well-characterized. Using a novel transgenic mouse expressing the NKG2D ligand RAE1ε in ε-islet cells of the pancreas, we found RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets. This was dependent on NKG2D expression by the CTLs and independent of antigen recognition. Surprisingly, the recruitment of CTLs resulted in the subsequent recruitment of a large number of endogenous lymphocytes. While transgenic mice did not develop diabetes, RAE1 expression was sufficient to induce insulitis in older, unmanipulated transgenic mice that was enhanced by viral infection and pancreatic inflammation. These results demonstrate that the expression of NKG2D ligands in islets is sufficient to recruit CTLs and induce a significant insulitis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Biljana Zafirova (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi http www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Markiewicz, Mary A.; Wise, Erica L.; Buchwald, Zachary S.; Pinto, Amelia K.; , Zafirova, Biljana; Polić, Bojan; Shaw, Andrey .
RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition // Immunity, 36 (2012), 1; 132-141 doi:10.1016/j.immuni.2011.11.014 (međunarodna recenzija, članak, znanstveni)
Markiewicz, M., Wise, E., Buchwald, Z., Pinto, A., , Zafirova, Biljana, Polić, B. & Shaw, A. (2012) RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition. Immunity, 36 (1), 132-141 doi:10.1016/j.immuni.2011.11.014.
@article{article, author = {Markiewicz, Mary A. and Wise, Erica L. and Buchwald, Zachary S. and Pinto, Amelia K. and Poli\'{c}, Bojan and Shaw, Andrey .}, year = {2012}, pages = {132-141}, DOI = {10.1016/j.immuni.2011.11.014}, keywords = {T cells, NKG2D, pancreatic islets, Rae1, insulitis}, journal = {Immunity}, doi = {10.1016/j.immuni.2011.11.014}, volume = {36}, number = {1}, issn = {1074-7613}, title = {RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition}, keyword = {T cells, NKG2D, pancreatic islets, Rae1, insulitis} }
@article{article, author = {Markiewicz, Mary A. and Wise, Erica L. and Buchwald, Zachary S. and Pinto, Amelia K. and Poli\'{c}, Bojan and Shaw, Andrey .}, year = {2012}, pages = {132-141}, DOI = {10.1016/j.immuni.2011.11.014}, keywords = {T cells, NKG2D, pancreatic islets, Rae1, insulitis}, journal = {Immunity}, doi = {10.1016/j.immuni.2011.11.014}, volume = {36}, number = {1}, issn = {1074-7613}, title = {RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition}, keyword = {T cells, NKG2D, pancreatic islets, Rae1, insulitis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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