Naslov
CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses

Autori
Soderquest, Katrina ; Walzer, Thierry ; Zafirova, Biljana ; Klavinskis, Linda S. ; Polić, Bojan ; Vivier, Eric ; Lord, Graham M. ; Martín-Fontecha, Alfonso

Izvornik
Journal of immunology (0022-1767) 186 (2011), 6; 3304-3308

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cells; memory CD8+ T cells; NKG2D; OT1

Sažetak
It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8(+) T cell fate by killing recently activated CD8(+) T cells in an NKG2D- and perforin-dependent manner. In the absence of NK cells, the differentiation of CD8(+) T cells is strongly biased toward a central memory T cell phenotype. Although, on a per-cell basis, memory CD8(+) T cells generated in the presence or the absence of NK cells have similar functional features and recall capabilities, NK cell deletion resulted in a significantly higher number of memory Ag-specific CD8(+) T cells, leading to more effective control of tumors carrying model Ags. The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA