Pregled bibliografske jedinice broj: 537210
Modulation of the synaptic drive to respiratory premotor and motor neurons
Modulation of the synaptic drive to respiratory premotor and motor neurons // Respiratory physiology, 110 (1997), 2-3; 161-176 (podatak o recenziji nije dostupan, članak, znanstveni)
CROSBI ID: 537210 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Modulation of the synaptic drive to respiratory premotor and motor neurons
Autori
McCrimmon, DR ; Zuperku, EJ ; Hayashi, F ; Đogaš, Zoran ; Hinrichsen, CF ; Stuth, EA ; Tonković-Čapin, Mislav ; Krolo, Mirko ; Hopp, FA
Izvornik
Respiratory physiology (0149-2950) 110
(1997), 2-3;
161-176
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
respiratory neurons; synapse; modulation
Sažetak
The characteristics of GABAergic inhibitory modulation of respiratory bulbospinal neuronal activity and short-term potentiation (STP) of phrenic motoneuronal activity were studied. Extracellular unit recording and picoejection techniques in anesthetized dogs showed that both the spontaneous rhythmic and reflexly induced discharge patterns of inspiratory (I) and expiratory (E) premotor neurons were proportionately amplified by the localized application of picomole amounts of bicuculline (Bic), a competitive GABAA antagonist. Intracellular recording and paired-pulse stimulation techniques in anesthetized rats demonstrated an STP of phrenic motor output that appears to be mediated by NMDA receptors and is associated with facilitation of EPSPs and prolonged depolarization of individual phrenic motoneurons. We speculate that both GABAergic gain modulation of premotor neuronal activity and NMDA-mediated STP of phrenic activity may be neural substrates which are involved with the optimization of respiratory and non-respiratory behaviors, via adaptive and/or differential control of breathing.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
