Naslov
The Effect of Topical Hyaluronic Acid in Patients with Burning Mouth Syndrome

Autori
Vučićević Boras, Vanja ; Canjuga, Ivana ; Brailo, Vlaho ; Vidović Juras, Danica

Izvornik
Acta stomatologica Croatica (0001-7019) 45 (2011), 2; 141-141

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
burning mouth syndrome; hyaluronic acid

Sažetak
It has been reported that 0.2% hyaluronic acid (HA) might be beneficial in certain oral diseases such as recurrent aphthous ulcers and oral lichen planus due to its anti-inflammatory and other properties (1). Furthermore, HA is a hygroscopic macromolecule and solutions are highly osmotic. In the skin and perhaps on the oral mucosa, this property is likely to be relevant in controlling tissue hydration during periods of change such as the inflammatory process or response to tissue injury (2). Burning mouth syndrome is a still enigmatic condition for the patient and the doctor albeit extensive literature reports could be found. Unfortunately there is no effective treatment for BMS (3). In 19 patients with burning mouth syndrome a thorough clinical examination was performed as well as hematological investigation which involved complete blood count, iron, feritin and the BMS diagnosis was established according to the Scala et al.(4). HA was prescribed in the form of gel (Gengigel®, Ricerfarma, Italy) to be applied three times a day. After one year the participants were interviewed by the telephone. Out of 19 participants, we could reach only 12. In four patients complete BMS remission was reported after HA has been used for one month. In two patients the burning symptoms were reduced but were still present and in six patients burning symptoms were unaffected by use of HA, i.e. HA was not useful in BMS symptoms. It is possible that immediate application reduces discomfort and this is purely a barrier or protective mechanism from stimuli arising in the oral environment. On the other hand, complete remission of BMS might be solely attributed to the placebo effect which remains to be elucidated in further studies. However, we were satisfied as some patients were free of symptoms no matter what caused BMS remission.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

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