Naslov
The influence of type 1 diabetes mellitus on glucose, adipokines, and essential fatty acids

Autori
Ivanišević, Marina ; Đelmiš, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 43rd annual meeting of DPSG / Simmons, David ; Dornhorst, Anne ; Murphy, helen ; Temple, Rosemary - Cambridge : DPSG, 2011, 48-49

Skup
The 43rd annual meeting of DPSG

Mjesto i datum
Cambridge, Ujedinjeno Kraljevstvo, 22.09.2011. - 24.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
type 1 diabetes mellitus; glucose; adipokines; essential fatty acids

Sažetak
Objective. The goal of this study was to define the influence of type 1 DM on levels of glucose, insulin, c-peptide, leptin, adiponectin, total free fatty aids (FFA), and essential fatty acids (EFA) in maternal and umbilical vein blood. Methods. Research included (58) pregnant women divided into two groups as follows: 28 healthy pregnant women (CTRL) and 30 pregnant women with type 1 DM. Maternal vein blood samples and umbilical vein and artery blood samples during delivery were taken and glucose concentration along with insulin, C-peptide, leptin, adiponectin, and FFA were meas¬ured. Extraction of total lipids was performed according Folch method. For extraction of the fatty acids, gas chromatography was used. Results. Mean values in maternal blood of the CTRL were: glu¬cose 4.1 ±1.6 mmol/L, insulin 12.8±1.7U/mL, C-peptide 315.2±201.1 ng/mL, leptin 1003.9±621.8 ng/ mL, adiponectin 17.3±4.55 |jg/mL. Values measured from umbilical vein blood in CTRL group were: glucose 3.3±1.3 mmol/L, insulin 3.47 U/L, C-peptide 105.7±87.9 ng/mL, leptin 400.3±354.6 ng/mL, adiponectin 4.8±3.5 pg/mL, In maternal blood of type 1 DM values were: glucose 5.4±4.8, insulin 21.1 ±8.7 U/mL, C-peptid 319± 230 ng/mL, leptin 720.4 ± 952.0 ng/mL, adiponectin 9.3±7.9 yg/mL. In umbilical vein of mothers with type 1 DM we measured: glucose 3.1 ± 2.1 mmol/L, insulin 11.0±4.2 U/mL, C-peptide 257.0±234.8 ng/mL, leptin 1240.8±989.7 ng/mL, adiponectin 40.6±55.2 |jg/mL. Fetal macrosomia is associated with higher concentration of leptin. C peptide correlates very well with birthweight of the newborns and shows increased values among newborns of diabetic mothers even when they are eutrophic compared to the eutrophic newborns of the controls. The statistical significant difference was found in total lipid content in pregnant women between the studied groups (CTRL 6881.7±2311.3 mg/L: type 1 DM 7553.8±4822.9 mg/L). In the umbilical vein the concentra¬tion of the total lipd contents was lower in both groups 1899±862.6 vs. 2636.1 ±904.8 mg/L com¬pared to the respective artery 2588.91 ±892.63 vs. 2728.7±1327.4 mg/L) what suggests that fetus of the diabetic mother synthesizes additional lipids. We did not find any statistical significant difference between maternal and umbilical vein plasma concentration of EFA between two groups. The con¬centration of docosahexaenoic (DHA) acid in umbilical artery plasma was higher in CTRL group compared to type 1 DM group (3.17% : 2.43%). The relative concentrations of arachidonic acid (AA) and DHA in umbilical vein plasma in both groups were higher when compared with maternal venous plasma in both groups. There were found statistically significant higher relative concentrations of AA in umbilical vein plasma in CTRL and in type 1 DM groups (11.7% ; 13.6%) when compared with maternal vein plasma in both groups ( CTRL=1.6% ; type 1 DM =1.9%).

Izvorni jezik
Engleski

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