Naslov
The impact of prepregnancy BMI and weight gain during pregnancy on pregnancy outcome among women with GDM.

Autori
Juras, Josip ; Ivanisević, Marina ; Herman, Mislav ; Horvatiček, Marina ; Anzulović, Dunja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXXIII Alpe Adria Meeting of Perinatal Medicine / Đelmiš, Josip ; Ivanišević, Marina ; Juretić, Emilja - Zagreb : Hrvatsko društvo za perinatalnu medicinu HLZ-a, 2011, 41-41

ISBN
953645179-1

Skup
XXXIII Alpe Adria Meeting of Perinatal Medicine

Mjesto i datum
Zagreb, Hrvatska, 30.09.2011. - 01.10.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
pregnancy; weight gain; gestational diabetes mellitus

Sažetak
Introduction. Obesity is one of risk factors for impaired glucose metabolism, preeclampsia and adverse pregnancy outcome. Prepregnancy body mass index correlates with perinatal outcome, but weight gain during pregnancy seems to have an important influence on birth weight. Aim. The aim of this study was to explore weather prepregnancy BMI or weight gain during pregnancy had bigger influence on perinatal outcome among GDM women vs. controls. Materials and methods. This is a historical cohort study. The data of one decade period till 2010 from our clinic was analyzed. It included 3741 singleton pregnancies. Women were divided into 4 subgroups according to their diagnosis and prepregnancy BMI. Results. Both BMI and maternal weight gain were positively correlated to neonatal birth weight, but weight gain had bigger correlation coefficient than BMI (r=0.256, r=0.158 ; p<0.001, respectively). There was a statistically significant difference between subgroups in birth weight and ponderal index. The biggest birth weight and ponderal index had children form GDM mothers with BMI ≥25, the smallest were in control group with BMI <25. The results of standard multiple linear regression showed that maternal weight gain had higher influence to birth weight than BMI (R2=0.011, ΔR2=0.114 ; p<0.001). GDM women with BMI ≥25 had the highest rate of macrosomic neonate (30.1%) among other groups (χ2=103.053 ; p<0.001). The rate of preterm birth was likewise highest (9.2%, χ2=12.92 ; p=0.005). According to greater weight gained women had macrosomic neonate more often. The likelihood ratio for women who gained 10-16 kilos was 0.895, but with 20-24 and 24-30 kilos gained rates were 1.577 and 2.965, respectively. Having GDM there is 1.61 RR of having macrosomic neonate in relation to control group. GDM women with BMI ≥25 had 1.49 RR (95% CI 1.41 – 1.85 ; p<0.001) for macrosomic child in relation to GDM women with BMI <25 (95% CI 1.22 – 1.81 ; p<0.001). Conclusion. Considering BMI and weight gain as predictor parameters for perinatal outcome it can be concluded that weight gain has higher predictive value compared to BMI. Women with larger BMI and weight gain have more adverse perinatal outcome and is getting poorer as BMI and weight continue to rise.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA