Naslov
Immunohistochemical detection of TGFa and EGF-R, c- erbB2, c-H-ras, c-myc, estrogen and progesterone in benign and malignant human breast lesions: a concomitant expression?

Autori
Spaventi, Radan ; Kamenjicki, Elena ; Pećina, Nives ; Grazio, Snježana ; Grazio, Simeon ; Pavelić, Jasminka ; Kušić, Borka ; Cvrtila, Dragutin ; Danilović, Z. ; Spaventi, Šime ; Pavelić, Krešimir ; Gluckman, J. ; Pavelić, Zlatko

Izvornik
In vibatisti (Athens) (0258-851X) 8 (1994); 183-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
TGF-alpha ; EGF-R ; c-erbB-2 ; c-H-ras ; c-myc ; progesterone ; estrogen ; breast lesions

Sažetak
The expression of transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R) and oncogenes c-erbB-2, c-H-ras, c-myc, as well as estrogen (ER) and progesterone (PR) receptors were studied immunohistochemically in the tissue of 21 benign and 58 malignant human breast lesions. Twenty nine (50%) of 58 carcinomas were positive for EGF-R and c-erbB-2 product, 55 (94.8%) for c-myc product, 9 (15.5%) for c-H-ras product and 17 (29%) for TGF- alpha. Eighteen of 58 (31%) carcinomas were estrogen receptor positive and 22 (38%) were positive for progesterone receptor. No correlation was found between expression of each investigated parameter and the clinical stage of degree of histological differentiation of the carcinomas. However, a significant positive correlation was observed between lymph node involment and c-erbB-2 and EGF- R/c-erbB-2 positive tumors. A strong correlation was also observed between high levels of EGF-R and low levels of estrogen receptor. In 15 of 17 cases we found simultaneous expression of EGF-R and TGF- alpha. We also found interesting patterns in concomitant expression of the investigated parameters suggesting a possible cascade of events that occur in breast cancer cells.

Izvorni jezik
Engleski

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